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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제19권 제2호
- 발행연도
- 2016.1
- 수록면
- 116 - 122 (7page)
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초록· 키워드
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Purpose: We aimed to investigate the efficacy and safety of adalimumab in pediatric-onset Crohn’s disease patients who had failed treatment with infliximab.Methods: In this retrospective study, patients included were those who had been diagnosed with Crohn’s disease before 18 years old, and had received treatment with adalimumab after infliximab failure. The efficacy of adalimumab treatment was investigated at 1 month and 1 year, and adverse events that had occurred during treatment with adali-mumab were explored. Results: Ten patients were included in this study. The median duration from diagnosis to adalimumab treatment was 5.5 years (range: 2.4-7.9 years). At 1 month after adalimumab initiation, 80% (8/10) of patients showed clinical response, and 40% (4/10) achieved clinical remission. At 1 year, 71% (5/7) of patients showed clinical response, and 43% (3/7) were under clinical remission. Among the total included patients, 5 patients (50%) showed clinical response at 1 year. Primary non-response to adalimumab was observed in 2 patients (20%), and secondary failure to adalimumab was observed in 3 patients (30%) during 1 year treatment with adalimumab. No serious adverse event had occurred during adalimumab treatment. Conclusion: Adalimumab was effective for 1 year without serious adverse events in half of pediatric-onset Crohn’sdisease patients who had failed treatment with infliximab.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Baumgart DC / 2007 / Inflammatory bowel disease: clinical aspects and established and evolving therapies / Lancet 369:1641~1657
Louis E / 2001 / Behaviour of Crohn's disease according to the vienna classification: changing pattern over the course of the disease / Gut 49:777~782
Thia KT / 2010 / Risk factors associated with progression to intestinal complications of Crohn's disease in a population- based cohort / Gastroenterology 139:1147~1155
Hanauer SB / 2002 / Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial / Lancet 359:1541~1549
Sands BE / 2004 / Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study / Clin Gastroenterol Hepatol 2:912~920
Louis E / 2001 / Behaviour of Crohn's disease according to the vienna classification: changing pattern over the course of the disease / Gut 49:777~782
Thia KT / 2010 / Risk factors associated with progression to intestinal complications of Crohn's disease in a population- based cohort / Gastroenterology 139:1147~1155
Hanauer SB / 2002 / Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial / Lancet 359:1541~1549
Sands BE / 2004 / Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study / Clin Gastroenterol Hepatol 2:912~920
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