지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Objective. This study evaluates serum or urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) as a biomarker for lupus nephritis (LN). Methods. We conducted a meta-analysis examining serum or urinary TWEAK levels in patients with systemic lupus erythematosus (SLE), patients with LN (active or inactive), and healthy controls. We tabulated correlation coefficients between urinary TWEAK level and total or renal SLE Disease Activity Index (tSLEDAI or rSLEDAI). Results. Eight studies were included in this meta-analysis. The meta-analysis revealed that serum TWEAK levels tended to be higher in patients with SLE than in controls (standard mean difference [SMD]=0.850, 95% confidence interval [CI]=−0.067∼1.767, p=0.069). Urinary TWEAK was significantly higher in patients with active LN than in those with inactive LN (SMD=2.865, 95% CI= −0.831∼4.898, p=0.006). In addition, urinary TWEAK was positively associated with tSLEDAI and rSLEDAI (correlation coefficient= 0.436, 95% CI=0.204∼0.622, p=4.3×10−4; correlation coefficient=0.483, 95% CI=0.108∼0.738, p=0.014). Pooled sensitivity and specificity of urinary TWEAK for diagnosis of LN were 81.3% (95% CI, 73.3∼87.8) and 76.0% (95% CI, 66.3∼84.2), indicating good diagnostic accuracy. Conclusion. The meta-analysis demonstrated that urinary TWEAK was significantly higher in patients with active LN than in those with inactive LN, and that urinary TWEAK levels were positively correlated with renal disease activity. (J Rheum Dis 2017;24:85-92)
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Waldman M / 2006 / Update on the treatment of lupus nephritis / Kidney Int 70:1403~1412
Lech M / 2013 / The pathogenesis of lupus nephritis / J Am Soc Nephrol 24:1357~1366
Ogura Y / 2013 / Proinflammatory cytokine tumor necrosis factor(TNF)-like weak inducer of apoptosis(TWEAK)suppresses satellite cell self-renewal through inversely modulating Notch and NF-κB signaling pathways / J Biol Chem 288:35159~35169
Winkles JA / 2008 / The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting / Nat Rev Drug Discov 7:411~425
Campbell S / 2006 / Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells / J Immunol 176:1889~1898
Lech M / 2013 / The pathogenesis of lupus nephritis / J Am Soc Nephrol 24:1357~1366
Ogura Y / 2013 / Proinflammatory cytokine tumor necrosis factor(TNF)-like weak inducer of apoptosis(TWEAK)suppresses satellite cell self-renewal through inversely modulating Notch and NF-κB signaling pathways / J Biol Chem 288:35159~35169
Winkles JA / 2008 / The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting / Nat Rev Drug Discov 7:411~425
Campbell S / 2006 / Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells / J Immunol 176:1889~1898
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Is Urinary Tumor Necrosis Factor-like Weak Inducer of Apoptosis a Biomarker of Lupus Nephritis?
대한류마티스학회지
2017 .01
-
Worse Renal Presentation and Prognosis in Initial-Onset Lupus Nephritis than Early-Onset Lupus Nephritis
Yonsei Medical Journal
2020 .01
-
Evaluating the association of interleukin-10 gene promoter -592 A/C polymorphism with lupus nephritis susceptibility
Kidney Research and Clinical Practice
2016 .01
-
Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
대한류마티스학회지
2022 .10
-
Chronologic trends of cancer-related lymph node research in PubMed: informetrics analysis
Annals of Surgical Treatment and Research
2020 .11
-
Circulating Interleukin-37 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Correlations With Disease Activity: A Meta-analysis
대한류마티스학회지
2020 .01
-
Clinical significance of lymph node size in locally advanced cervical cancer treated with concurrent chemoradiotherapy
Journal of Yeungnam Medical Science
2019 .01
-
The impact of lymph node count on survival in gastric cancer
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .12
-
Meta-analysis of Circulating Adiponectin, Visfatin, and Ghrelin Levels in Patients with Systemic Lupus Erythematosus
대한류마티스학회지
2017 .01
-
Urinary Incontinence and Lower Urinary Tract Symptoms for Community-Dwelling Older Adults in Jeju
성인간호학회 학술대회
2015 .04
-
The prognosis factors among breast cancer patients with extensive axillary lymph node metastasis
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .06
-
Urobiome: An outlook on the metagenome of urological diseases
Investigative and Clinical Urology
2021 .11
-
Is the Initial Size of Tuberculous Lymphadenopathy associated with Lymph Node Enlargement during Treatment?
Infection and Chemotherapy
2017 .06
-
Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis
대한류마티스학회지
2021 .01
-
Self-Reported Physical Activity Is Associated with Lupus Nephritis in Systemic Lupus Erythematosus: Data from KORean Lupus Network (KORNET) Registry
Yonsei Medical Journal
2018 .01
-
Potential Biomarkers for Diagnosis of Overactive Bladder Patients: Urinary Nerve Growth Factor, Prostaglandin E2, and Adenosine Triphosphate
International Neurourology Journal
2017 .01
-
Outcomes of Drug-Resistant Urinary Retention in Patients in the Early Stage of Stroke
Annals of Rehabilitation Medicine
2015 .01
-
Distribution of Lymph Nodes in Stage III Patients With Mid and Low Rectal Cancer: Preliminary Study
Annals of Coloproctology
2018 .01
-
Circulating Interleukin-18 Level in Systemic Lupus Erythematosus
대한류마티스학회지
2020 .01
-
Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
Clinical Psychopharmacology and Neuroscience
2017 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0