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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제3호
- 발행연도
- 2017.8
- 수록면
- 269 - 275 (7page)
- DOI
- https://doi.org/10.9758/cpn.2017.15.3.269
이용수
초록· 키워드
오류제보하기
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.
Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.
Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls.
Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Modabbernia A / 2013 / Cytokine alterations in bipolar disorder : a meta-analysis of 30studies / Biol Psychiatry 74:15~25
Munkholm K / 2013 / Cytokines in bipolar disorder vs. healthy control subjects:a systematic review and meta-analysis / J Psychiatr Res 47:1119~1133
Munkholm K / 2013 / Cytokines in bipolar disorder : a systematic review and meta-analysis / J Affect Disord 144:16~27
Teixeira AL / 2015 / Increased plasma levels of soluble TNF receptors 1 and 2 in bipolar depression and impact of lithium treatment / Hum Psychopharmacol 30:52~56
Dean B / 2013 / Different changes in cortical tumor necrosis factor--related pathways in schizophrenia and mood disorders / Mol Psychiatry 18:767~773
Munkholm K / 2013 / Cytokines in bipolar disorder vs. healthy control subjects:a systematic review and meta-analysis / J Psychiatr Res 47:1119~1133
Munkholm K / 2013 / Cytokines in bipolar disorder : a systematic review and meta-analysis / J Affect Disord 144:16~27
Teixeira AL / 2015 / Increased plasma levels of soluble TNF receptors 1 and 2 in bipolar depression and impact of lithium treatment / Hum Psychopharmacol 30:52~56
Dean B / 2013 / Different changes in cortical tumor necrosis factor--related pathways in schizophrenia and mood disorders / Mol Psychiatry 18:767~773
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