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To review B-cell activating factor (BAFF)-antagonist therapy in systemic lupus erythematosus (SLE), literature was searched using the search words and phrases, “BAFF”, “B lymphocyte stimulator (BLyS)”, “a proliferation-inducing ligand (APRIL)”, “B-cell maturation antigen (BCMA)”, “transmembrane activator and calcium-modulating and cyclophilin ligand interactor (TACI)”, “BLyS receptor 3 (BR3)”, “belimumab”, “atacicept”, “blisibimod”, “tabalumab”, and “lupus clinical trial”. In addition, papers from the author’s personal library were searched. BAFF-antagonist therapy in SLE has a checkered past, with four late-stage clinical trials meeting their primary endpoints and four failing to do so. Additional late-stage clinical trials are enrolling subjects to address some of the remaining unresolved questions, and novel approaches are proposed to improve results. The BAFF-centric pathway is a proven therapeutic target in SLE. As the only pathway in the past 50+ years to have yielded an United States Food and Drug Administration-approved drug for SLE, it occupies a unique place in the armamentarium of the practicing rheumatologist. The challenges facing clinicians and investigators are how to better tweak the BAFF-centric pathway and improve on the successes realized. (J Rheum Dis 2017;24:65-73)
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참고문헌 (83)
참고문헌 신청
Schneider P / 1999 / BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth / J Exp Med 189:1747~1756
Moore PA / 1999 / BLyS : member of the tumor necrosis factor family and B lymphocyte stimulator / Science 285:260~263
Nardelli B / 2001 / Synthesis and release of B-lymphocyte stimulator from myeloid cells / Blood 97:198~204
Laabi Y / 1994 / The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed / Nucleic Acids Res 22:1147~1154
von Bülow GU / 1997 / NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily / Science 278:138~141
Moore PA / 1999 / BLyS : member of the tumor necrosis factor family and B lymphocyte stimulator / Science 285:260~263
Nardelli B / 2001 / Synthesis and release of B-lymphocyte stimulator from myeloid cells / Blood 97:198~204
Laabi Y / 1994 / The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed / Nucleic Acids Res 22:1147~1154
von Bülow GU / 1997 / NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily / Science 278:138~141
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