개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.10 No.5
- 발행연도
- 2018.1
- 수록면
- 562 - 569 (8page)
이용수
초록· 키워드
오류제보하기
Sublingual immunotherapy (SLIT) is an effective treatment for allergic diseases. However, the mechanism by which this therapy exhibits its efficacy has not been fully delineated. To elucidate the mechanisms of SLIT in the treatment of cedar pollinosis (CP), we performed a multivariate analysis of microarray data on mRNA expression in CD4+ T cells and basophils. Although 2-year treatment with SLIT using cedar extracts was effective in > 70% of patients with CP, the remaining patients did not respond to this therapy. The mRNA expression levels in peripheral CD4+ T cells and basophils from both high- and non-responder patients before and after undergoing SLIT were comparatively studied using microarray analysis. By processing the data using serial multivariate analysis, an apoptosis pathway was extracted in both CD4+ T cells and basophils. Conclusively, the strong treatment effectiveness of SLIT in patients with CP may be caused by the induction of apoptosis in CD4+ T cells and basophils in these patients (Trial registry at University Hospital Medical Information Network Clinical Trials Registry Database, UMIN000016532).
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Fujieda S / 2012 / Examination, diagnosis and classification for Japanese allergic rhinitis: Japanese guideline / Auris Nasus Larynx 39:553~556
Yamada T / 2014 / Present state of Japanese cedar pollinosis: The national affliction / J Allergy Clin Immunol 133:632~639
손명현 / 2018 / Efficacy and Safety of Subcutaneous Allergen Immunotherapy for Allergic Rhinitis / Allergy, Asthma & Immunology Research 10(1):1~3
Mitobe Y / 2015 / Safety evaluation of standardized allergen extract of Japanese cedar pollen for sublingual immunotherapy / Regul Toxicol Pharmacol 71:529~540
Horiguchi S / 2008 / A randomized controlled trial of sublingual immunotherapy for Japanese cedar pollinosis / Int Arch Allergy Immunol 146:76~84
Yamada T / 2014 / Present state of Japanese cedar pollinosis: The national affliction / J Allergy Clin Immunol 133:632~639
손명현 / 2018 / Efficacy and Safety of Subcutaneous Allergen Immunotherapy for Allergic Rhinitis / Allergy, Asthma & Immunology Research 10(1):1~3
Mitobe Y / 2015 / Safety evaluation of standardized allergen extract of Japanese cedar pollen for sublingual immunotherapy / Regul Toxicol Pharmacol 71:529~540
Horiguchi S / 2008 / A randomized controlled trial of sublingual immunotherapy for Japanese cedar pollinosis / Int Arch Allergy Immunol 146:76~84
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The KAAACI Guidelines for Sublingual Immunotherapy
Allergy, Asthma & Immunology Research
2024 .01
-
Basophil Markers for Identification and Activation in the Indirect Basophil Activation Test by Flow Cytometry for Diagnosis of Autoimmune Urticaria
Annals of Laboratory Medicine
2016 .01
-
Effectiveness of Specific Sublingual Immunotherapy in Korean Patients with Atopic Dermatitis
Annals of Dermatology
2017 .01
-
Outcome of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitive to House Dust Mites
Allergy, Asthma & Immunology Research
2015 .01
-
Efficacy of Sublingual Immunotherapy for House Dust Mite-Induced Allergic Rhinitis: A Meta-Analysis of Randomized Controlled Trials
Allergy, Asthma & Immunology Research
2017 .01
-
Three-Year Follow-up Results of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitized to House Dust Mites
Allergy, Asthma & Immunology Research
2015 .01
-
Basophil Activation Test for Chronic Urticaria
Annals of Laboratory Medicine
2016 .01
-
Comparison of Patient Satisfaction between Subcutaneous Immunotherapy and Sublingual Immunotherapy in Allergic Rhinitis
대한이비인후-두경부외과학회지
2016 .01
-
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
Endocrinology and Metabolism
2017 .01
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites
Allergy, Asthma & Immunology Research
2018 .01
-
Sublingual Immunotherapy for Japanese Cedar Pollinosis Attenuates Asthma Exacerbation
Allergy, Asthma & Immunology Research
2019 .01
-
Effect of Peripheral Blood CD4 + CD25 + Regulatory T Cell on Postoperative Immunotherapy for Patients with Renal Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
혈중 호염기구 수에 따른 성인 천식의 임상 양상 분석 및 호기 응축물 내 사이토카인과의 연관성 분석
Allergy Asthma & Respiratory Diseases
2020 .01
-
Short-, Intermediate-, and Long-Term Changes in Basophil Reactivity Induced by Venom Immunotherapy
Allergy, Asthma & Immunology Research
2016 .01
-
Increased Expression of miR-146a in Children With Allergic Rhinitis After Allergen-Specific Immunotherapy
Allergy, Asthma & Immunology Research
2016 .01
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
Sublingual Immunotherapy in Asian Children: 2-Year Follow-Up Results
Journal of Rhinology
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0