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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Ana Rodríguez Trabado (Ciudad de Coria Hospital Allergy Department)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.8 No.5
발행연도
2016.1
수록면
412 - 420 (9page)

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Purpose: The basophil activation test (BAT) has been used to monitor venom immunotherapy (VIT) due to its high specificity. A previous study has reported a good correlation between a significant decrease in basophil activation during 5 years of VIT and clinical protection assessed by sting challenge. The following prospective study was performed to examine changes in basophil reactivity over a complete VIT period of 5 years. Methods: BAT in a dose-response curve was studied prospectively in 10 hymenoptera venom-allergic patients over 5 years of VIT. BAT was performed at the time of diagnosis, 1 month after finishing the VIT build-up phase, and 3, 6, 12, 24, and 60 months after beginning treatment. The repeated measures ANOVA was applied to evaluate basophil activation changes throughout VIT. A cross-sectional study was also performed in 6 patients who received treatment for more than 3 years, and in another 12 patients who followed immunotherapy for at least 5 years. Results: An early activation decrease was observed during the first 3 months of treatment, compared to pre-treatment values. This activation decrease was not maintained 6 to 18 months after treatment, but was observed again after 2 years of treatment, and maintained until the completion of the 5-year immunotherapy period. In cross-sectional analysis, the 6 patients who received treatment for 3 years, and 9 of the 12 patients who received treatment for 5 years, had negative BAT results. Three patients in this last group had positive BAT results and 2 patients had systemic reactions after field stings. Conclusions: BAT appears to be an optimal non-invasive test for close monitoring of VIT.

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참고문헌 (44)

참고문헌 신청
Müller U / 1992 / Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety / J Allergy Clin Immunol 89:529~535 google schola Golden DB / 2005 / Insect sting allergy and venom immunotherapy: a model and a mystery / J Allergy Clin Immunol 115:439~447 google schola Ruëff F / 2001 / Patients still reacting to a sting challenge while receiving conventional Hymenoptera venom immunotherapy are protected by increased venom doses / J Allergy Clin Immunol 108:1027~1032 google schola Keating MU / 1991 / Clinical and immunologic follow-up of patients who stop venom immunotherapy / J Allergy Clin Immunol 88:339~348 google schola van Halteren HK / 1997 / Discontinuation of yellow jacket venom immunotherapy: followup of 75 patients by means of deliberate sting challenge / J Allergy Clin Immunol 100:767~770 google schola

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