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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 113 - 118 (6page)
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An FDA approved drug for the treatment of type II diabetes, Troglitazone (TRO), a peroxisome proliferator–activated receptor gamma agonist, is withdrawn due to severe idiosyncratic hepatotoxicity. In the search for new applications of TRO, we investigated the cellular effects of TRO on YD15 tongue carcinoma cells. TRO suppressed the growth of YD15 cells in the MTT assay. The inhibition of cell growth was accompanied by the induction of cell cycle arrest at G0/G1 and apoptosis, which are confirmed by flow cytometry and western blotting. TRO also suppressed the expression of cell cycle proteins such as cyclin D1, cdk2, cdk4, cyclin B1, cdk1(or cdc2), cyclin E1 and cyclin A. The inhibition of cell cycle proteins was coincident with the up-regulation of p21CIP1/WAF1 and p27KIP1. In addition, TRO induces the activation of caspase-3 and caspase-7, as well as the cleavage of PARP. Further, TRO suppressed the expressions of Bcl-2 without affecting the expressions of Bad and Bax. Overall, our data supports that TRO induces cell cycle arrest and apoptosis on YD15 cells.
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참고문헌 (27)
참고문헌 신청
Umamaheswar Duvvuri / 2009 / Cancer of the head and neck is the sixth most common cancer worldwide / Current Problems in Surgery 46(2):114~117
Petersen PE / 2005 / Strengthening the prevention of oral cancer: the WHO perspective / Community Dentistry and Oral Epidemiology 33(6):397~399
M. Hashibe / 2009 / Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium / Cancer Epidemiology Biomarkers & Prevention 18(2):541~550
Gypsyamber D'Souza / 2007 / Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer / New England Journal of Medicine 356(19):1944~1956
Blot WJ / 1988 / Smoking and drinking in relation to oral and pharyngeal cancer / Cancer Res 48:3282~3287
Petersen PE / 2005 / Strengthening the prevention of oral cancer: the WHO perspective / Community Dentistry and Oral Epidemiology 33(6):397~399
M. Hashibe / 2009 / Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium / Cancer Epidemiology Biomarkers & Prevention 18(2):541~550
Gypsyamber D'Souza / 2007 / Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer / New England Journal of Medicine 356(19):1944~1956
Blot WJ / 1988 / Smoking and drinking in relation to oral and pharyngeal cancer / Cancer Res 48:3282~3287
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