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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 507 - 517 (11page)
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초록· 키워드
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The bark of Magnolia officinalis has been used in traditional oriental medicine to treat a variety of mental disorders including anxiety and depression. The purpose of this study was to examine the effect of M. officinalis ethanol extract on stress-induced alterations in learning and cognitive function using a passive avoidance test (PAT) and also on anxiety-related behavior using the elevated plus-maze test (EPM) in female rats . The degree of Tyrosine hydroxylase (TH) in the region of the ventral tegmental area (VTA) and the locus coeruleus (LC) was measured using an immunohistochemical method. Corticosterone concentrations in serum were also measured. The ethanol extract from Magnolia officinalis was orally administered to female rats 30 minutes before evaluating their immobilization stress and anxiety-related behavior using an elevated plus-maze test and a passive avoidance test.
Time spent in the open arms of the EPM increased in the M. officinalis-treated group compared with that of the saline-treated control group. In the passive avoidance test, the memory and cognitive function improved in the M. officinalis extract-treated group. M. officinalis extracts reduced elevated corticosterone concentrations in serum. Also, stress-induced TH increases were suppressed in the M. officinalis extract-treated group in the LC and the VTA region.
These results suggest that M. officinalis might prove to be an effective anxiolytic anti-stress agent.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Argyropoulos SV / 2000 / The psychobiology of anxiolytic drug. Part 2:Pharmacological treatments of anxiety / Pharmacol Ther 88 (3) : 213 ~ 227
Imaizumi M / 2000 / Animal models of ‘anxiety' / Nihon Yakurigaku Zasshi 115 (1) : 5 ~ 12
Ito K / 1982 / Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb / Chem Pharm Bull(Tokyo) 30 (9) : 3347 ~ 3353
Kamei J / 2009 / Involvement of the benzodiazepine system in the anxiolytic-like effect of Yokukansan(Yi-gan san) / Prog Neuropsychopharmacol Biol Psychiatry 33 (8) : 1431 ~
Kaneko A / 2005 / Hange-koboku-to, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA(noradrenaline) and DA(dopamine) in mice / Phytotherapy Resea
Imaizumi M / 2000 / Animal models of ‘anxiety' / Nihon Yakurigaku Zasshi 115 (1) : 5 ~ 12
Ito K / 1982 / Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb / Chem Pharm Bull(Tokyo) 30 (9) : 3347 ~ 3353
Kamei J / 2009 / Involvement of the benzodiazepine system in the anxiolytic-like effect of Yokukansan(Yi-gan san) / Prog Neuropsychopharmacol Biol Psychiatry 33 (8) : 1431 ~
Kaneko A / 2005 / Hange-koboku-to, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA(noradrenaline) and DA(dopamine) in mice / Phytotherapy Resea
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