지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 690 - 697 (8page)
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초록· 키워드
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Purpose: High-sensitivity assays enabled the identification of C-reactive protein (hs-CRP) at levels that were previously undetectable.
We aimed to determine if hs-CRP could reflect airway inflammation in children, by comparing hs-CRP with spirometry and impulse oscillometry (IOS) parameters and symptomatic severities.
Materials and Methods: A total of 276 asthmatic children who visited Severance Children’s Hospital from 2012–2014 were enrolled.
Serum hs-CRP and pulmonary function tests were performed on the same day. Patients were divided into hs-CRP positive and negative groups (cut-off value, 3.0 mg/L).
Results: Of the 276 asthmatic children [median age 7.5 (5.9/10.1) years, 171 boys (62%)], 39 were hs-CRP positive and 237 were negative. Regarding spirometry parameters, we observed significant differences in maximum mid-expiratory flow, % predicted (FEF25–75) (p=0.010) between hs-CRP positive and negative groups, and a negative correlation between FEF25–75 and hs-CRP. There were significant differences in the reactance area (AX) (p=0.046), difference between resistance at 5 Hz and 20 Hz (R5–R20) (p=0.027), resistance at 5 Hz, % predicted (R5) (p=0.027), and reactance at 5 Hz, % predicted (X5) (p=0.041) between hs-CRP positiveand negative groups. There were significant positive correlations between hs-CRP and R5 (r=0.163, p=0.008), and X5 (r=0.164, p=0.007). Spirometry and IOS parameters had more relevance in patients with higher blood neutrophil levels in comparison to hs-CRP.
Conclusion: Hs-CRP showed significant correlation with FEF25–75, R5, and X5. It can reflect small airway obstruction in childhood asthma, and it is more prominent in neutrophil dominant inflammation.
목차
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참고문헌 (39)
참고문헌 신청
van de Kant KD / 2009 / Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control study / BMC Public Health 9:210
Deraz TE / 2012 / High-sensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry / Pediatr Pulmonol 47:220~225
Busse WW / 2001 / Asthma / N Engl J Med 344:350~362
Jousilahti P / 2002 / The association of sensitive systemic inflammation markers with bronchial asthma / Ann Allergy Asthma Immunol 89:381~385
Hoshino M / 2014 / Increased C-reactive protein is associated with airway wall thickness in steroid-naive asthma / Ann Allergy Asthma Immunol 113:37~41
Deraz TE / 2012 / High-sensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry / Pediatr Pulmonol 47:220~225
Busse WW / 2001 / Asthma / N Engl J Med 344:350~362
Jousilahti P / 2002 / The association of sensitive systemic inflammation markers with bronchial asthma / Ann Allergy Asthma Immunol 89:381~385
Hoshino M / 2014 / Increased C-reactive protein is associated with airway wall thickness in steroid-naive asthma / Ann Allergy Asthma Immunol 113:37~41
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