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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 824 - 828 (5page)
이용수
초록· 키워드
오류제보하기
Objective The pathogenesis of depression is not fully understood yet, but studies have suggested higher circulating C reactive protein (CRP) level might relate to depression occurrence. However, due to high variability of patients’ individual condition, the results to date are inconsistent. Considering CRP single-nucleotide polymorphisms (SNPs) could also regulate plasma CRP levels, in the present study, we hypothesized that inherited CRP allelic variations may co-vary with depressive symptomatology. Methods We recruited 60 depression patients with family depression history and 60 healthy control volunteers into this project. We detected circulation CRP level as well as genome CRP SNPs from participants of this project. Results We have found a significantly higher circulating CRP level in patients with a positive family history. Furthermore, we also identified some certain inherited CRP SNPs (A allele in rs1417938 and C allele in rs1205) could up regulate serum CRP level and distributed more in depression patients with family history. Conclusion Our finding may raise new evidence that genetically increased serum CRP level through SNPs variation is likely to induce family inherited depression.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Devaraj S / 2010 / Role of C-reactive protein incontributing to increased cardiovascular risk in metabolic syndrome / Curr Atheroscler Rep 12:110~118
Sun M / 2016 / The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb / Neurobiol Dis 93:1~11
McDade TW / 2015 / C-reactive protein response to influenza vaccination as a model of mild inflammatory stimulation in the Philippines / Vaccine 33:2004~2008
Siedlinski M / 2012 / Association of cigarette smoking and CRP levels with DNA methylation in ${\alpha}$ -1 antitrypsin deficiency / Epigenetics 7:720~728
Lucassen PJ / 2015 / Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation / Cold Spring Harb Perspect Biol 7:a021303
Sun M / 2016 / The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb / Neurobiol Dis 93:1~11
McDade TW / 2015 / C-reactive protein response to influenza vaccination as a model of mild inflammatory stimulation in the Philippines / Vaccine 33:2004~2008
Siedlinski M / 2012 / Association of cigarette smoking and CRP levels with DNA methylation in
Lucassen PJ / 2015 / Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation / Cold Spring Harb Perspect Biol 7:a021303
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