지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 351 - 362 (12page)
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BACKGROUND: Osteoarthritis (OA) in the temporomandibular joint (TMJ) in the TMJ (TMJ-OA) is difficult to treat, and new alternative treatments are needed. Recently, adipose-derived stem cells (ASCs) have been introduced as a promising cell source because of their anti-inflammatory effects. However, the cost and availability of these cells limited broader applications of stem cell therapy. Thus, Thus, stromal vascular fraction (SVF) containing sufficient amount of ASCs at low cost can be an alternative. In this study, we aimed to demonstrate the use of uncultured, optimally isolated SVF for the treatment of TMJ-OA. METHODS: First, we optimized the method of isolation to harvest high-quality SVFs with a large yield of ASCs. Then, we analyzed the quantity of ASCs in the SVF and performed characterization of stem cell homology. Subsequently, to evaluate the anti-inflammatory effect of high-quality SVF, an in vitro study was performed to assess the expression patterns of inflammatory cytokines including prostaglandin E2 (PGE2), IL-6, and CXCL8/IL-8, COX2, TNF, IFN, CCL2/MCP-1 and CCL5/RANTES in co-culture with synoviocytes derived from the synovial fluid in the TMJ-OA patients. RESULTS: The SVF containing approximately 32% ASCs was isolated via the our optimized isolation method. The SVF significantly down-regulated certain inflammatory cytokines such as PGE2, CXCL8/IL-8 in TMJ-OA tissue-derived synoviocytes. CONCLUSION: Although further study is needed, our study suggests that transplantation of adipose tissue-derived SVF cells might be a feasible and a novel therapeutic option for TMJ-OA in the future.
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참고문헌 (38)
참고문헌 신청
Stohler CS / 1999 / Craniofacial pain and motor function : pathogenesis, clinical correlates, and implications / Crit Rev Oral Biol Med 10:504~518
Dimitroulis G / 2005 / The role of surgery in the management of disorders of the temporomandibular joint : a critical review of the literature : part 2 / Int J Oral Maxillofac Surg 34:231~237
Loeser RF / 2012 / Osteoarthritis : a disease of the joint as an organ / Arthritis Rheum 64:1697~1707
Sellam J / 2010 / The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis / Nat Rev Rheumatol 6:625~635
Goldring M / 2008 / Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism / Ann Rheum Dis. 67:iii75~iii82
Dimitroulis G / 2005 / The role of surgery in the management of disorders of the temporomandibular joint : a critical review of the literature : part 2 / Int J Oral Maxillofac Surg 34:231~237
Loeser RF / 2012 / Osteoarthritis : a disease of the joint as an organ / Arthritis Rheum 64:1697~1707
Sellam J / 2010 / The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis / Nat Rev Rheumatol 6:625~635
Goldring M / 2008 / Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism / Ann Rheum Dis. 67:iii75~iii82
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