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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
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Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for stem cell effects because very few stem cells engraft after injection into recipient animals. Recently, nanovesicles that overcome the disadvantages of natural exosomes have been generated artificially from cells. We generated artificial nanovesicles from adipose-derived stem cells (ASCs) using sequential penetration through olycarbonate membranes. ASC-derived artificial nanovesicles displayed a 100 nm-sized spherical shape similar to ASC-derived natural exosomes and expressed both exosomal and stem cell markers. The proliferation rate of lung epithelial cells was increased in cells treated with ASC-derived artificial nanovesicles compared with cells treated with ASC-derived natural exosomes. The lower dose of ASC-derived artificial nanovesicles had similar regenerative capacity compared with a higher dose of ASCs and ASC-derived natural exosomes. In addition, FGF2 levels in the lungs of mice treated with ASC-derived artificial nanovesicles were increased. The uptake of ASC-derived artificial nanovesicles was inhibited by heparin, which is a competitive inhibitor of heparan sulfate proteoglycan that is associated with FGF2 signaling. Taken together, the data indicate that lower doses of ASC-derived artificial nanovesicles may have beneficial effects similar to higher doses of ASCs or ASC-derived natural exosomes in an animal model with emphysema, suggesting that artificial nanovesicles may have economic advantages that warrant future clinical studies.
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참고문헌 (23)
참고문헌 신청
Aguilar S / 2009 / Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis / PLoS ONE 4
Bonfield TL / 2010 / Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model / Am J Physiol Lung Cell Mol Physiol 299 : L760 ~
Bruno S / 2009 / Mesenchymal stem cell-derived microvesicles protect against acute tubular injury / J Am Soc Nephrol 20 : 1053 ~ 1067
Bruno S / 2012 / Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury / PLoS ONE 7 : e33115 ~
Cho KS / 2010 / Immunomodulatory effects of adipose-derived stem cells in airway allergic diseases / Curr Stem Cell Res Ther 5 : 111 ~ 115
Bonfield TL / 2010 / Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model / Am J Physiol Lung Cell Mol Physiol 299 : L760 ~
Bruno S / 2009 / Mesenchymal stem cell-derived microvesicles protect against acute tubular injury / J Am Soc Nephrol 20 : 1053 ~ 1067
Bruno S / 2012 / Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury / PLoS ONE 7 : e33115 ~
Cho KS / 2010 / Immunomodulatory effects of adipose-derived stem cells in airway allergic diseases / Curr Stem Cell Res Ther 5 : 111 ~ 115
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