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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 335 - 343 (9page)
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초록· 키워드
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BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there are no disease-modifying OA drugs, and the primary therapies include exercise and nonsteroidal anti-inflammatory drugs until total joint replacement at the end-stage of the disease. METHODS: In this review, we summarized the current state of knowledge in genetic and epigenetic associations and risk factors for OA and their potential diagnostic and therapeutic applications. RESULTS: Genome-wide association studies and analysis of epigenetic modifications (such as miRNA expression, DNA methylation and histone modifications) conducted across various populations support the notion that there is a genetic basis for certain subsets of OA pathogenesis. CONCLUSION: With recent advances in the development of genome editing technologies such as the CRISPR-Cas9 system, these genetic and epigenetic alternations in OA can be used as platforms from which potential biomarkers for the diagnosis, prognosis, drug response, and development of potential personalized therapeutic targets for OA can be approached. Furthermore, genome editing has allowed the development of “designer” cells, whereby the receptors, gene regulatory networks, or transgenes can be modified as a basis for new cell-based therapies.
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참고문헌 (86)
참고문헌 신청
Pereira D / 2011 / The effect of osteoarthritis definition on prevalence and incidence estimates : a systematic review / Osteoarthritis Cartilage 19:1270~1285
Hunter DJ / 2008 / The symptoms of osteoarthritis and the genesis of pain / Rheum Dis Clin North Am 34:623~643
Felson DT / 2004 / An update on the pathogenesis and epidemiology of osteoarthritis / Radiol Clin North Am 42:1~9
Blanco FJ / 2014 / Editorial: Is it time for epigenetics in osteoarthritis? / Arthritis Rheumatol 66:2324~2327
van Saase JL / 1989 / Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations / Ann Rheum Dis 48:271~280
Hunter DJ / 2008 / The symptoms of osteoarthritis and the genesis of pain / Rheum Dis Clin North Am 34:623~643
Felson DT / 2004 / An update on the pathogenesis and epidemiology of osteoarthritis / Radiol Clin North Am 42:1~9
Blanco FJ / 2014 / Editorial: Is it time for epigenetics in osteoarthritis? / Arthritis Rheumatol 66:2324~2327
van Saase JL / 1989 / Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations / Ann Rheum Dis 48:271~280
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