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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 155 - 162 (8page)
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초록· 키워드
오류제보하기
The extracellular matrix (ECM) is known to provide instructive cues for cell attachment, proliferation, differ- entiation, and ultimately tissue regeneration. The use of decellularized ECM scaffolds for regenerative-medicine approaches is rapidly expanding. In this study, cartilage acellular matrix (CAM)-based bioink was developed to fabricate functional biomolecule-containing scaffolds. The CAM provides an adequate cartilage tissue–favorable environment for chondrogenic differentiation of cells. Conventional manufacturing techniques such as salt leaching, solvent casting, gas forming, and freeze drying when applied to CAM-based scaffolds cannot precisely control the scaffold geometry for mimicking tissue shape. As an alternative to the scaffold fabrication methods, 3D printing was recently introduced in the field of tissue engineering. 3D printing may better control the internal microstructure and external appearance because of the computer-assisted construction process. Hence, applications of the 3D printing technology to tissue engineering are rapidly proliferating. Therefore, printable ECM-based bioink should be developed for 3D structure stratification. The aim of this study was to develop printable natural CAM bioink for 3D printing of a tissue of irregular shape. Silk fibroin was chosen to support the printing of the CAM powder because it can be physically cross-linked and its viscosity can be easily controlled. The newly developed CAM-silk bioink was evaluated regarding printability, cell viability, and tissue differ- entiation. Moreover, we successfully demonstrated 3D printing of a cartilage-shaped scaffold using only this CAM-silk bioink. Future studies should assess the efficacy of in vivo implantation of 3D-printed cartilage-shaped scaffolds.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Chan BP / 2008 / Scaffolding in tissue engineering: general approaches and tissue-specific considerations / Eur Spine J 17:467~479
Bolland F / 2007 / Development and characterisation of a full-thickness acellular porcine bladder matrix for tissue engineering / Biomaterials 28:1061~1070
Agmon G / 2016 / Controlling stem cell behavior with decellularized extracellular matrix scaffolds / Curr Opin Solid State Mater Sci 20:193~201
Wade RJ / 2012 / Engineering ECM signals into biomaterials / Mater Today (Kidlington) 15:454~459
Scarritt ME / 2015 / A review of cellularization strategies for tissue engineering of whole organs / Front Bioeng Biotechnol 3:43
Bolland F / 2007 / Development and characterisation of a full-thickness acellular porcine bladder matrix for tissue engineering / Biomaterials 28:1061~1070
Agmon G / 2016 / Controlling stem cell behavior with decellularized extracellular matrix scaffolds / Curr Opin Solid State Mater Sci 20:193~201
Wade RJ / 2012 / Engineering ECM signals into biomaterials / Mater Today (Kidlington) 15:454~459
Scarritt ME / 2015 / A review of cellularization strategies for tissue engineering of whole organs / Front Bioeng Biotechnol 3:43
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