지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1 - 13 (13page)
- DOI
- 10.1038/s12276-021-00697-6
이용수
초록· 키워드
오류제보하기
Osteoarthritis (OA) is significantly associated with diabetes, but how hyperglycemia induces or aggravates OA has not been shown. The synovium plays a critical role in cartilage metabolism and substance exchange. Herein, we intended to investigate whether and how hyperglycemia affects the occurrence and progression of OA by influencing the synovium. In patients with knee OA and diabetes (DM OA), we found a more severe inflammatory response, higher endoplasmic reticulum stress (ERS) levels, and more advanced glycosylation end products (AGEs) accumulation in the synovium than in patients without diabetes. Subsequently, we found similar results in the DM OA group in a rat model. In the in vitro cocultivation system, high glucose-stimulated AGEs accumulation, ERS, and inflammation in rat fibroblast-like synoviocytes (FLSs), which resulted in chondrocyte degeneration due to inflammatory factors from FLSs. Furthermore, in the synovium of the DM OA group and FLSs treated with high glucose, the expression of glucose transporter 1 (GLUT1) and its regulatory factor hypoxia-inducible factor (HIF)-1α was increased significantly. Inhibitors of HIF-1α, GLUT1 or AGEs receptors attenuated the effect of high glucose on chondrocyte degradation in the FLS-chondrocyte coculture system. In summary, we demonstrated that hyperglycemia caused AGEs accumulation in FLSs via the HIF-1α-GLUT1 pathway, which increases the release of inflammatory factors from FLSs, subsequently inducing chondrocyte degradation and promoting OA progression.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Crosstalk between FLS and chondrocytes is regulated by HIF-2α-mediated cytokines in arthritis
Experimental and Molecular Medicine
2015 .01
-
The mitochondrial unfolded protein response (UPRmt) protects against osteoarthritis
Experimental and Molecular Medicine
2022 .11
-
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
Experimental and Molecular Medicine
2021 .11
-
The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway
Experimental and Molecular Medicine
2022 .11
-
Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
조직공학과 재생의학
2019 .01
-
Differentiation of adipose-derived stem cells into functional chondrocytes by a small molecule that induces Sox9
Experimental and Molecular Medicine
2020 .01
-
Avenanthramide C as a novel candidate to alleviate osteoarthritic pathogenesis
BMB Reports
2021 .10
-
Dynamic synovial fibroblasts are modulated by NBCn1 as a potential target in rheumatoid arthritis
Experimental and Molecular Medicine
2022 .04
-
Graphene Oxide-Mediated Fluorometric Aptasensor for Okadaic Acid Detection
BioChip Journal
2022 .06
-
Thermosensitive Hydrogel Loaded with Primary Chondrocyte-Derived Exosomes Promotes Cartilage Repair by Regulating Macrophage Polarization in Osteoarthritis
조직공학과 재생의학
2022 .06
-
3D Printing 기술을 활용한 OA Level 에 따른 무릎 관절 모사 시스템 개발
한국정밀공학회 학술발표대회 논문집
2023 .11
-
Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis
BMB Reports
2018 .01
-
miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
Experimental and Molecular Medicine
2015 .01
-
IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes
Experimental and Molecular Medicine
2019 .01
-
Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300
Experimental and Molecular Medicine
2018 .01
-
Overcoming Current Dilemma in Cartilage Regeneration: Will Direct Conversion Provide a Breakthrough?
조직공학과 재생의학
2020 .01
-
Full Polarimetric SAR Decomposition Analysis of Landslide-affected Areas in Mocoa, Colombia
한국측량학회지
2017 .10
-
이코노마이저 외기 엔탈피 센서 오프셋 결함 발생에 따른 중간기 냉방 에너지 사용량 변화 및 실내 열환경 평가
대한건축학회논문집
2025 .03
-
m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p?AQP1/ANKH axis
Experimental and Molecular Medicine
2021 .11
-
Derivation and Differentiation of Bone Marrow Mesenchymal Stem Cells from Osteoarthritis Patients
조직공학과 재생의학
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0