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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 164 - 175 (12page)
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The activation of neurotrophic signaling pathways following the upregulation of glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-β family, has a potential neuroprotective effect in the adult brain. Herein, we report that hippocampal transduction of adeno-associated virus serotype 1 (AAV1) with a constitutively active form of ras homolog enriched in brain [Rheb(S16H)], which can stimulate the production of brain-derived neurotrophic factor (BDNF) in hippocampal neurons, induces the increases in expression of GDNF and GDNF family receptor α-1 (GFRα-1), in neurons and astrocytes in the hippocampus of rat brain in vivo. Moreover, upregulation of GDNF and GFRα-1 contributes to neuroprotection against thrombin-induced neurotoxicity in the hippocampus. These results suggest that AAV1-Rheb(S16H) transduction of hippocampal neurons, resulting in neurotrophic interactions between neurons and astrocytes, may be useful for neuroprotection in the adult hippocampus.
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참고문헌 (34)
참고문헌 신청
Paratcha G / 2008 / GDNF and GFRalpha : a versatile molecular complex for developing neurons / Trends Neurosci 31:384~391
Ayanlaja AA / 2018 / The reversible effects of glial cell line-derived neurotrophic factor(GDNF)in the human brain / Semin Cancer Biol 53:212~222
Airavaara M / 2011 / Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease / J Biol Chem 286:45093~45102
Konishi Y / 2014 / Deficiency of GDNF receptor GFRα1 in Alzheimer's neurons results in neuronal death / J Neurosci 34:13127~13138
Forlenza OV / 2015 / Decreased neurotrophic support is associated with cognitive decline in non-demented subjects / J Alzheimers Dis 46:423~429
Ayanlaja AA / 2018 / The reversible effects of glial cell line-derived neurotrophic factor(GDNF)in the human brain / Semin Cancer Biol 53:212~222
Airavaara M / 2011 / Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease / J Biol Chem 286:45093~45102
Konishi Y / 2014 / Deficiency of GDNF receptor GFRα1 in Alzheimer's neurons results in neuronal death / J Neurosci 34:13127~13138
Forlenza OV / 2015 / Decreased neurotrophic support is associated with cognitive decline in non-demented subjects / J Alzheimers Dis 46:423~429
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