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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 17 - 23 (7page)
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Astrocytes and neurons are inseparable partners in the brain. Neurotransmitters released from neurons activate corresponding G protein-coupled receptors (GPCR) expressed in astrocytes, resulting in release of gliotransmitters such as glutamate, D-serine, and ATP. These gliotransmitters in turn influence neuronal excitability and synaptic activities. Among these gliotransmitters, ATP regulates the level of network excitability and is critically involved in sleep homeostasis and astrocytic Ca2+ oscillations. ATP is known to be released from astrocytes by Ca2+-dependent manner. However, the precise source of Ca2+, whether it is Ca2+ entry from outside of cell or from the intracellular store, is still not clear yet. Here, we performed sniffer patch to detect ATP release from astrocyte by using various stimulation. We found that ATP was not released from astrocyte when Ca2+ was released from intracellular stores by activation of Gαq–coupled GPCR including PAR1, P2YR, and B2R. More importantly, mechanical stimulation (MS)-induced ATP release from astrocyte was eliminated when external Ca2+ was omitted. Our results suggest that Ca2+ entry, but not release from intracellular Ca2+ store, is critical for MS-induced ATP release from astrocyte.
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참고문헌 (26)
참고문헌 신청
Nedergaard M / 2002 / Beyond the role of glutamate as a neurotransmitter / Nat Rev Neurosci 3:748~755
Halassa MM / 2007 / The tripartite synapse: roles for gliotransmission in health and disease / Trends Mol Med 13:54~63
Haydon PG / 2006 / Astrocyte control of synaptic transmission and neurovascular coupling / Physiol Rev 86:1009~1031
Wang X / 2006 / Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo / Nat Neurosci 9:816~823
Pascual O / 2005 / Astrocytic purinergic signaling coordinates synaptic networks / Science 310:113~116
Halassa MM / 2007 / The tripartite synapse: roles for gliotransmission in health and disease / Trends Mol Med 13:54~63
Haydon PG / 2006 / Astrocyte control of synaptic transmission and neurovascular coupling / Physiol Rev 86:1009~1031
Wang X / 2006 / Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo / Nat Neurosci 9:816~823
Pascual O / 2005 / Astrocytic purinergic signaling coordinates synaptic networks / Science 310:113~116
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