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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제15권 제3호
- 발행연도
- 2016.1
- 수록면
- 61 - 67 (7page)
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Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as central nervous system.
Among the 3 common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleteriousrole of ε4 allele by atherosclerosis and amyloid beta accumulation in brain and body. The presence and gene dose of ε4 allele are risk factors forlate-onset Alzheimer’s disease. Apolipoprotein E ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationshipwith the early onset of late-onset Alzheimer’s disease. However, early-onset Alzheimer’s disease has a weaker relationship with ε4 allele of apolipoproteinE.
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참고문헌 (80)
참고문헌 신청
Corbo RM / 2006 / Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation / Mol Genet Metab 89:261~269
Nickerson DA / 2000 / Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene / Genome Res 10:1532~1545
박창훈 / 2010 / Discrepancy in Genotyping of Apolipoprotein E between Allele-Specific PCR and Fluorescence Resonance Energy Transfer or Sequencing / Annals of Laboratory Medicine 30(3):325~328
Scacchi R / 2003 / Screening of two mutations at exon 3 of the apolipoprotein E gene(sites 28 and 42)in a sample of patients with sporadic late-onset Alzheimer’s disease / Neurobiol Aging 24:339~343
Wernette-Hammond ME / 1989 / Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194 / J Biol Chem 264:9094~9101
Nickerson DA / 2000 / Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene / Genome Res 10:1532~1545
박창훈 / 2010 / Discrepancy in Genotyping of Apolipoprotein E between Allele-Specific PCR and Fluorescence Resonance Energy Transfer or Sequencing / Annals of Laboratory Medicine 30(3):325~328
Scacchi R / 2003 / Screening of two mutations at exon 3 of the apolipoprotein E gene(sites 28 and 42)in a sample of patients with sporadic late-onset Alzheimer’s disease / Neurobiol Aging 24:339~343
Wernette-Hammond ME / 1989 / Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194 / J Biol Chem 264:9094~9101
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