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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 267 - 276 (10page)
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Background: Impaired diastolic heart function has been observed in persons with non-alcoholic fatty liver disease (NAFLD) and/or with type 2 diabetes mellitus (T2DM). However, it is unclear whether NAFLD fibrotic progression, i.e., non-alcoholic steatohepatitis, poses an independent risk for diastolic dysfunction in T2DM. We investigated the association between liver fibrosis and left ventricular (LV) diastolic dysfunction in T2DM. Methods: We analyzed 606 patients with T2DM, aged ≥50 years, who had undergone liver ultrasonography and pulsed-wave Doppler echocardiography. Insulin sensitivity was measured by short insulin tolerance test. Presence of NAFLD and/or advanced liver fibrosis was determined by abdominal ultrasonography and NAFLD fibrosis score (NFS). LV diastolic dysfunction was defined according to transmitral peak early to late ventricular filling (E/A) ratio and deceleration time, using echocardiography. Results: LV diastolic dysfunction was significantly more prevalent in the NAFLD versus non-NAFLD group (59.7% vs. 49.0%, P=0.011). When NAFLD was stratified by NFS, subjects with advanced liver fibrosis exhibited a higher prevalence of diastolic dysfunction (49.0%, 50.7%, 61.8%; none, simple steatosis, advanced fibrosis, respectively; P for trend=0.003). In multivariable logistic regression, liver fibrosis was independently associated with diastolic dysfunction (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.07 to 2.34; P=0.022) after adjusting for insulin resistance and cardiometabolic risk factors. This association remained significant in patients without insulin resistance (OR, 4.32; 95% CI, 1.73 to 11.51; P=0.002). Conclusions: Liver fibrosis was associated with LV diastolic dysfunction in patients with T2DM and may be an independent risk factor for diastolic dysfunction, especially in patients without systemic insulin resistance.
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참고문헌 (41)
참고문헌 신청
Loomba R / 2013 / The global NAFLD epidemic / Nat Rev Gastroenterol Hepatol 10:686~690
Browning JD / 2004 / Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity / Hepatology 40:1387~1395
Farrell GC / 2013 / NAFLD in Asia : as common and important as in the west / Nat Rev Gastroenterol Hepatol 10:307~318
Musso G / 2016 / Non-alcoholic steatohepatitis : emerging molecular targets and therapeutic strategies / Nat Rev Drug Discov 15:249~274
Wong RJ / 2015 / Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States / Gastroenterology 148:547~555
Browning JD / 2004 / Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity / Hepatology 40:1387~1395
Farrell GC / 2013 / NAFLD in Asia : as common and important as in the west / Nat Rev Gastroenterol Hepatol 10:307~318
Musso G / 2016 / Non-alcoholic steatohepatitis : emerging molecular targets and therapeutic strategies / Nat Rev Drug Discov 15:249~274
Wong RJ / 2015 / Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States / Gastroenterology 148:547~555
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