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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 226 - 233 (8page)
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초록· 키워드
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Nonalcoholic fatty liver disease (NAFLD) is thought to stem from the body’s inability to store excess energy in adipocytes; as such,it is commonly viewed as the hepatic manifestation of metabolic syndrome. The pathogenesis of NAFLD involves ectopic fat accumulation, which also takes place in the liver, muscle and visceral fat. NAFLD is rapidly becoming more widespread in Korea, withan estimated prevalence of 30% in adults. Type 2 diabetes mellitus (T2DM) and NAFLD share insulin resistance as a commonpathophysiological mechanism, and each of these two diseases affects the development of the other. Recent studies have suggestedthat NAFLD is often present as a comorbidity in T2DM patients. The mutual interrelationship between these conditions is shown byfindings suggesting that T2DM can exacerbate NAFLD by promoting progression to nonalcoholic hepatosteatosis or fibrosis, whileNAFLD causes the natural course of diabetic complications to worsen in T2DM patients. It remains unknown whether one disease isthe cause of the other or vice versa. In this review, I would like to discuss current epidemiological data on the associations betweenNAFLD and T2DM, and how each disease affects the course of the other.
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등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Byrne CD / 2015 / NAFLD: a multisystem disease / J Hepatol 62(1 Suppl):S47~S64
Browning JD / 2004 / Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity / Hepatology 40:1387~1395
Bugianesi E / 2005 / Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease : sites and mechanisms / Diabetologia 48:634~642
Marchesini G / 2001 / Nonalcoholic fatty liver disease : a feature of the metabolic syndrome / Diabetes 50:1844~1850
이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45
Browning JD / 2004 / Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity / Hepatology 40:1387~1395
Bugianesi E / 2005 / Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease : sites and mechanisms / Diabetologia 48:634~642
Marchesini G / 2001 / Nonalcoholic fatty liver disease : a feature of the metabolic syndrome / Diabetes 50:1844~1850
이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45
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