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Identification of high-risk subjects in nonalcoholic fatty liver disease
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논문 기본 정보

Type
Academic journal
Author
Christiane Stern (Service d’Hépatologie Hôpital Beaujon Assistance Publique-Hôpitaux de Paris (AP-HP) Clichy) Laurent Castera (Service d’Hépatologie Hôpital Beaujon Assistance Publique-Hôpitaux de Paris (AP-HP) Clichy; Université Paris Cité UMR 1149 (CRI) INSERM Paris France)
Journal
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제29권 KCI Accredited Journals
Published
2023.2
Pages
196 - 206 (11page)

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Identification of high-risk subjects in nonalcoholic fatty liver disease
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Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease worldwide, and its burden is expected to increase due to the growing epidemic of obesity and diabetes. The key challenge among NAFLD patients is to identify those with advanced fibrosis (F3F4), who are at high risk of developing complications and will benefit from specialized management and treatment with new pharmacotherapies when they are approved. Liver biopsy appears unrealistic and unsuitable in practice, given the large number of high-risk patients and its well-known limitations. Non-invasive sequential algorithms using fibrosis-4 index as first-line test, followed by vibration-controlled transient elastography or patented blood test, are the best strategy for case finding of high-risk subjects. In fact, they are now recommended by several international guidelines, and should be used and disseminated to increase awareness among physicians beyond liver clinics where most NAFLD patients are seen.
#Non-alcoholic fatty liver disease #Elastography #Vibration controlled transient elastography #FibroScan #Liver fibrosis

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