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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 243 - 259 (17page)
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초록· 키워드
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Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver diseases and can progress to advanced fibrosis and end-stageliver disease. Thus, intensive research has been performed to develop noninvasive methods for the diagnosis of nonalcoholic steatohepatitis (NASH) and fibrosis. Currently, no single noninvasive tool covers all of the stages of pathologies and conditions ofNAFLD, and the cost and feasibility of known techniques are also important issues. Blood biomarkers for NAFLD may be useful toselect subjects who need ultrasonography (US) screening for NAFLD, and noninvasive tools for assessing fibrosis may be helpful toexclude the probability of significant fibrosis and to predict advanced fibrosis, thus guiding the decision of whether to perform liverbiopsy in patients with NAFLD. Among various methods, magnetic resonance-based methods have been shown to perform betterthan other methods in assessing steatosis as well as in detecting hepatic fibrosis. Many genetic markers are associated with the development and progression of NAFLD. Further well-designed studies are needed to determine which biomarker panels, imaging studies, genetic marker panels, or combinations thereof perform well for diagnosing NAFLD, differentiating NASH and fibrosis, andfollowing-up NAFLD, respectively.
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참고문헌 (117)
참고문헌 신청
Allen AM / 2018 / Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death : a 20 year-community study / Hepatology 67:1726~1736
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:73~84
Park SH / 2006 / Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults / J Gastroenterol Hepatol 21(1 Pt 1):138~143
정은행 / 2013 / Regional prevalence of non-alcoholic fatty liver disease in Seoul and Gyeonggi-do, Korea / Clinical and Molecular Hepatology 19(3):266~272
Portillo-Sanchez P / 2015 / High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels / J Clin Endocrinol Metab 100:2231~2238
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:73~84
Park SH / 2006 / Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults / J Gastroenterol Hepatol 21(1 Pt 1):138~143
정은행 / 2013 / Regional prevalence of non-alcoholic fatty liver disease in Seoul and Gyeonggi-do, Korea / Clinical and Molecular Hepatology 19(3):266~272
Portillo-Sanchez P / 2015 / High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels / J Clin Endocrinol Metab 100:2231~2238
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