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자료유형
학술저널
저자정보
김혜정 (순천향대학교) 배지철 (성균관대학교) 박형규 (순천향대학교) 변동원 (순천향대학교) 서교일 (순천향대학교) 유명희 (순천향대학교) Jae Hyeon Kim (Sungkyunkwan University School of Medicine) 민용기 (성균관대학교) 김선욱 (성균관대학교) 정재훈 (성균관대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.31 No.2
발행연도
2016.1
수록면
311 - 319 (9page)

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Background: Recent studies have shown an association between thyroid hormone levels and metabolic syndrome (MetS) amongeuthyroid individuals; however, there have been some inconsistencies between studies. Here, we evaluated the relationship betweenthyroid hormone levels and MetS in euthyroid middle-aged subjects in a large cohort. Methods: A retrospective analysis of 13,496 euthyroid middle-aged subjects who participated in comprehensive health examinationswas performed. Subjects were grouped according to thyroid stimulating hormone, total triiodothyronine (T3), total thyroxine(T4), and T3-to-T4 ratio quartile categories. We estimated the odds ratios (ORs) for MetS according to thyroid hormone quartilesusing logistic regression models, adjusted for potential confounders. Results: Of the study patients, 12% (n=1,664) had MetS. A higher T3 level and T3-to-T4 ratio were associated with unfavourablemetabolic profiles, such as higher body mass index, systolic and diastolic blood pressure, triglycerides, fasting glucose andglycated hemoglobin, and lower high density lipoprotein cholesterol levels. The proportion of participants with MetS increasedacross the T3 quartile categories (P for trend <0.001) and the T3-to-T4 ratio quartile categories (P for trend <0.001). The multivariate-adjusted OR (95% confidence interval) for MetS in the highest T3 quartile group was 1.249 (1.020 to 1.529) compared tothe lowest T3 quartile group, and that in the highest T3-to-T4 ratio quartile group was 1.458 (1.141 to 1.863) compared to thelowest T3-to-T4 ratio quartile group, even after adjustment for potential confounders. Conclusion: Serum T3 levels and T3-to-T4 ratio are independently associated with MetS in euthyroid middle-aged subjects. Longitudinal studies are needed to define this association and its potential health implications.

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