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자료유형
학술대회자료
저자정보
Dool-Ri Oh (Jeonnam Institute of Natural Resources Research) Yujin Kim (Jeonnam Institute of Natural Resources Research) Kyo-Nyeo Oh (Jeonnam Institute of Natural Resources Research) Eun-Jin Choi (Jeonnam Institute of Natural Resources Research) Donghyuck Bae (Jeonnam Institute of Natural Resources Research) Yonguk Kim (Jeonnam Institute of Natural Resources Research) Chulyung Choi (Chosun University)
저널정보
한국식품영양과학회 한국식품영양과학회 학술대회발표집 2021 KFN International Symposium and Annual Meeting [초록집]
발행연도
2021.10
수록면
337 - 337 (1page)

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Vaccinium bracteatum Thunb. (VB) are a component of traditional herbal medicines found in East Asia, specially, fruit is commonly known as the oriental blueberry in Korea. The present study aimed to evaluate the mechanisms underlying the antidepressant, preventing oxidative stress and insomnia of water extract of VB fruit (VBFW) using in vitro and in vivo models. First, since the serotonin neurotransmitter system is hypothesized to contribute to depression, we studied the effects of water extract from VBFW on the serotonin receptors (5-HTRs)-related activities in Chinese hamster ovary (CHO)-K1 cells transfected with the human 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT6, and 5-HT7 receptors. VBFW produced the antagonistic effects at the 5-HT2A receptors, and showed the agonistic effects at the 5-HT1A receptors, which could possibly produce antidepressant-like effects. Next, it was studied by using animal models predictive of antidepressant-like effects. The effects of VBFW were studied in normal and 4-Chloro-DL-phenylalanine methyl ester hydrochloride (PCPA)-induced serotonin-depleted mice. These results suggest that evidence of the antidepressant-like effects of VBFW includes the decreased immobility time during the forced swim test (FST) in mice that is caused by a decrease in the levels of serum corticosterone (CORT), as well as increased serotonergic neurotransmission. Moreover, this study provides an evidence that the antidepressant-like effects of VBFW in mice exposed ... 전체 초록 보기

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