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자료유형
학술저널
저자정보
Dool-Ri Oh (Jeonnam Institute of Natural Resources Research) Yujin Kim (Jeonnam Institute of Natural Resources Research) Ara Jo (Jeonnam Institute of Natural Resources Research) Sojeong Im (Jeonnam Institute of Natural Resources Research) Cho Een Kim (Jeonnam Institute of Natural Resources Research) Myung-A Jung (Jeonnam Institute of Natural Resources Research) Jawon Shin (Jeonnam Institute of Natural Resources Research) Huwon Kang (Jeonnam Institute of Natural Resources Research) Eun Jin Choi (Jeonnam Institute of Natural Resources Research) Jaeyong Kim (Jeonnam Institute of Natural Resources Research) Chulyung Choi (Jeonnam Institute of Natural Resources Research)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제34권 제2호
발행연도
2020.4
수록면
88 - 96 (9page)
DOI
10.15188/kjopp.2020.04.34.2.88

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Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) are herbal extracts widely used in food and traditional herbal medicine, and have the ability to perform a wide range of biological activities. We aimed to investigate the effects of the SH and VB combination (SHVB) on mice models of chronic restraint stress (CRS) and pentobarbital-induced sleeping behaviors to elucidate its possible mechanisms of action. CRS-exposed mice treated with SHVB showed significantly decreased immobility time, increased swimming and climbing times in the forced swim test (FST), and increased locomotor activity in the open field test (OFT). SHVB decreased serum CORT levels, but enhanced brain monoamine neurotransmitters. SHVB significantly decreased the sleep latency and increased total sleep duration in pentobarbital-induced sleeping behavior in mice. SHVB showed inhibitory effect on 5-HT2A receptor-mediated ERK1/2 phosphorylation. These results suggest that SHVB has antidepressant and hypnotic effects by regulating the 5-HT2A receptor.

목차

Introduction
Materials and Methods
Results
Discussion
References

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