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논문 기본 정보

자료유형
학술저널
저자정보
Kim Yong Sung (Wonkwang Digestive Disease Research Institute Wonkwang University Iksan KoreaGood Breath Clinic Gun) Lee Joonki (Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea) Shin Aesun (Scientific Committee Korean College of Helicobacter and Upper Gastrointestinal Research Seoul Korea) Lee Jung Min (Department of Gastroenterology Wonkwang University Sanbon Hospital Gunpo Korea) Park Jong Heon (National Health Insurance Service Wonju Korea) Jung Hwoon-Yong (Scientific Committee Korean College of Helicobacter and Upper Gastrointestinal Research Seoul Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제4호
발행연도
2021.1
수록면
537 - 545 (9page)

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Background/Aims: The incidence of peptic ulcer disease has decreased in past decades; however, the trends in peptic ulcer bleeding (PUB) are inconsistent among regions. This study aimed to investigate the trends in PUB incidence and the effect of risk factors on PUB in Korea. Methods: The records of patients hospitalized with PUB from 2006 to 2015 were retrieved from the Korean National Health Insurance Service Database. Standardized incidences of PUB were calculated, and the clinical characteristics such as age, sex, Helicobacter pylori infection, drug exposure, comorbidities, and mortality were obtained. Results: In total, 151,507 hospitalizations with PUB were identified. The overall annual hospitalization rate was 34.98 per 100,000 person-years. The incidence of PUB showed no significant change from 2006 to 2008 and decreased from 2008 to 2015, with an annual change of ?2.7% (p<0.05); however, this change was only significant in men. The incidence of PUB was higher in men than in women between 40 and 70 years old and higher in women than in men older than 80 years. From 2006 to 2015, the H. pylori infection rate increased significantly in patients with PUB; however, there was no significant change in exposure to nonsteroidal anti-inflammatory drugs or other drugs that increase the risk of PUB. Conclusions: Over the past decade, the incidence of PUB has decreased in a sex-specific manner. There has been a decreasing trend in the H. pylori infection rate and no change in exposure to drugs that increase the risk of PUB in Korea.
#Anti-inflammatory agents #non-steroidal #Helicobacter pylori #Peptic ulcer hemorrhage #Sex #Incidence

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참고문헌 (31)

참고문헌 신청
Lanas A / 2017 / Peptic ulcer disease / Lancet 390:613~624 google schola Lassen A / 2006 / Complicated and uncomplicated peptic ulcers in a Danish county 1993-2002 : a population-based cohort study / Am J Gastroenterol 101:945~953 google schola Post PN / 2006 / Declining incidence of peptic ulcer but not of its complications : a nation-wide study in The Netherlands / Aliment Pharmacol Ther 23:1587~1593 google schola Lewis JD / 2002 / Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s : relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medications / Am J Gastroenterol 97:2540~2549 google schola Wu CY / 2009 / A nationwide populationbased cohort study shows reduced hospitalization for peptic ulcer disease associated with H pylori eradication and proton pump inhibitor use / Clin Gastroenterol Hepatol 7:427~431 google schola

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