지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 346 - 352 (7page)
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초록· 키워드
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Background/Aims: The connection between Helicobacter pylori and complicated peptic ulcer disease in peptic ulcer bleeding (PUB) patients taking nonsteroidal anti-inflammatory drugs has not been established. In this study, we sought to determine whether delayed H. pylori eradication therapy in PUB patients increases complicated recurrent peptic ulcers. Methods: We identified inpatient PUB patients using the Taiwan National Health Insurance Research Database. We categorized patients into early (time lag ≤120 days after peptic ulcer diagnosis) and late H. pylori eradication therapy groups. The Cox proportional hazards model was used. The primary outcome was rehospitalization for patients with complicated recurrent peptic ulcers. Results: Our data indicated that the late H. pylori eradication therapy group had a higher rate of complicated recurrent peptic ulcers (hazard ratio [HR], 1.52; p=0.006), with time lags of more than 120 days. However, our results indicated a similar risk of complicated recurrent peptic ulcers (HR, 1.20; p=0.275) in time lags of more than 1 year and (HR, 1.10; p=0.621) more than 2 years. Conclusions: H. pylori eradication within 120 days was associated with decreased complicated recurrent peptic ulcers in patients with PUB. We recommend that H. pylori eradication should be conducted within 120 days in patients with PUB.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bianchi Porro G / 1999 / The conflicting relationship between Helicobacter pylori and non-steroidal anti-inflammatory drugs in peptic ulcer bleeding / Scand J Gastroenterol
Cameron EA / 2006 / Long-term study of re-infection following successful eradication of Helicobacter pylori infection / Aliment Pharmacol Ther 23 : 1355 ~ 1358
Chang SS / 2013 / Helicobacter pylori is not the predominant etiology for liver cirrhosis patients with peptic ulcer disease / Eur J Gastroenterol Hepatol 25 : 159 ~ 165
Chen TS / 2010 / Prevalence of Helicobacter pylori infection in duodenal ulcer and gastro-duodenal ulcer diseases in Taiwan / J Gastroenterol Hepatol 25 : 919 ~ 922
Cheng SH / 1997 / The effect of universal health insurance on health care utilization in Taiwan. Results from a natural experiment / JAMA 278 : 89 ~ 93
Cameron EA / 2006 / Long-term study of re-infection following successful eradication of Helicobacter pylori infection / Aliment Pharmacol Ther 23 : 1355 ~ 1358
Chang SS / 2013 / Helicobacter pylori is not the predominant etiology for liver cirrhosis patients with peptic ulcer disease / Eur J Gastroenterol Hepatol 25 : 159 ~ 165
Chen TS / 2010 / Prevalence of Helicobacter pylori infection in duodenal ulcer and gastro-duodenal ulcer diseases in Taiwan / J Gastroenterol Hepatol 25 : 919 ~ 922
Cheng SH / 1997 / The effect of universal health insurance on health care utilization in Taiwan. Results from a natural experiment / JAMA 278 : 89 ~ 93
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