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논문 기본 정보

자료유형
학술저널
저자정보
Kanghyug Choi (Department of Internal Medicine Seoul National University Bundang Hospital) Hee Yoon Jang (Department of Internal Medicine Seoul National University Bundang Hospital) Joong Mo Ahn (Department of Radiology Seoul National University Bundang Hospital) Sung Ho Hwang (Department of Nursing Daewon Univeristy College) Jung Wha Chung (Department of Internal Medicine Wonkwang University Sanbon Hospital) Yun Suk Choi (Department of Internal Medicine Seoul National University Bundang Hospital) Jin-Wook Kim (Departments of Internal Medicine Seoul National University Bundang Hospital) Eun Sun Jang (Department of Internal Medicine Seoul National University Bundang Hospital) Gwang Hyeon Choi (Department of Internal Medicine Seoul National University Bundang Hospital) Sook-Hyang Jeong (Department of Internal Medicine Seoul National University Bundang Hospital)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제26권 제4호
발행연도
2020.1
수록면
492 - 505 (14page)

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Background/Aims: The role of serum myokine levels in sarcopenia and the outcome of hepatocellular carcinoma (HCC) patients are not clear. This study investigated the serum levels of myostatin, follistatin, and interleukin-6 (IL-6) in HCC patients and their association with sarcopenia and survival. Methods: Using prospectively collected pretreatment samples from 238 HCC patients in a hospital from 2012 to 2015, the serum levels of 3 myokines were determined and compared to 50 samples from age and sex-matched healthy controls. Sarcopenia was evaluated using the psoas muscle index (PMI) measured at the third lumbar level in the computed tomography, and clinical data were collected until 2017. Results: The median levels of the 3 myokines for the male and female HCC patients were as follow: myostatin (3,979.3 and 2,976.3 pg/mL), follistatin (2,118.5 and 2,174.6 pg/mL), and IL-6 (2.5 and 2.7 pg/mL), respectively. Those in the HCC patients were all significantly higher than in the healthy controls. In the HCC patient, the median PMI was 4.43 (males) and 2.17 cm2/m2 (females) with a sarcopenic prevalence of 56.4%. The serum levels of myostatin, IL-6 and follistatin in the HCC patients showed a positive, negative, and no correlation with PMI, respectively. The serum follistatin level was an independent factor for poor survival in HCC patients. Conclusions: The serum levels of myostatin, follistatin, and IL-6 and their correlation with sarcopenia and survival were presented in HCC patients for the first time. The role of the serum follistatin level as a poor prognostic biomarker warrants further study.
#Hepatocellular carcinoma #Myostatin #Follistatin #Interleukin 6 #Sarcopenia

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참고문헌 (49)

참고문헌 신청
Landi F / 2014 / Calf circumference, frailty and physical performance among older adults living in the community / Clin Nutr 33:539~544 google schola Mijnarends DM / 2013 / Validity and reliability of tools to measure muscle mass, strength, and physical performance in community-dwelling older people : a systematic review / J Am Med Dir Assoc 14:170~178 google schola Cruz-Jentoft AJ / 2010 / Sarcopenia : European consensus on definition and diagnosis : report of the European Working Group on sarcopenia in older people / Age Ageing 39:412~423 google schola Beaudart C / 2014 / Prevalence of sarcopenia : the impact of different diagnostic cut-off limits / J Musculoskelet Neuronal Interact 14:425~431 google schola Zillikens MC / 1992 / Whole-body and segmental bioelectrical-impedance analysis in patients with cirrhosis of the liver : changes after treatment of ascites / Am J Clin Nutr 55:621~625 google schola

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