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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 535 - 542 (8page)
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Background/Aims: Hepatocellular carcinoma (HCC) patients with spinal metastasis (SM) show heterogeneous lengths of survival. In this study, we develop and propose a graded prognostic assessment for HCC patients with SM (HCC-SM GPA).
Methods: We previously reported the outcomes of 192 HCC patients with SM who received radiotherapy from April 1992 to February 2012. Prognostic factors that significantly affected survival in that study were used to establish the HCCSM GPA. Validation was performed using an independent cohort of 63 patients recruited from September 2011 to March 2016. Results: We developed the HCC-SM GPA using the following factors: Eastern Cooperative Oncology Group performance status (0?2, 0 point; 3?4, 1 point), controlled primary HCC (yes, 0 point; no, 2 points), and extrahepatic metastases other than bone (no, 0 point; yes, 1 point). Patients were stratified into low (GPA=0), intermediate (GPA=1 to 2), and high risk (GPA=3 to 4). When applied to the validation cohort, the HCC-SM GPA determined median survival durations of 13.6, 4.8, and 2.6 months and 1-year overall survival rates of 58.3%, 17.8%, and 7.3% for the low-, intermediate-, and highrisk patient groups, respectively (p<0.001). Conclusions: Our newly proposed HCC-SM GPA successfully predicted survival outcomes.
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참고문헌 (36)
참고문헌 신청
Fukutomi M / 2001 / Increased incidence of bone metastases in hepatocellular carcinoma / Eur J Gastroenterol Hepatol 13:1083~1088
Santini D / 2014 / Natural history of malignant bone disease in hepatocellular carcinoma: final results of a multicenter bone metastasis survey / PLoS One 9:e105268
Goodwin CR / 2016 / A systematic review of metastatic hepatocellular carcinoma to the spine / World Neurosurg 91:510~517.e4
최지환 / 2015 / Predictive Factors of Palliative Radiotherapy Response and Survival in Patients with Spinal Metastases from Hepatocellular Carcinoma / Gut and Liver 9(1):94~102
He J / 2011 / Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation / BMC Cancer 11:492
Santini D / 2014 / Natural history of malignant bone disease in hepatocellular carcinoma: final results of a multicenter bone metastasis survey / PLoS One 9:e105268
Goodwin CR / 2016 / A systematic review of metastatic hepatocellular carcinoma to the spine / World Neurosurg 91:510~517.e4
최지환 / 2015 / Predictive Factors of Palliative Radiotherapy Response and Survival in Patients with Spinal Metastases from Hepatocellular Carcinoma / Gut and Liver 9(1):94~102
He J / 2011 / Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation / BMC Cancer 11:492
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