Serum Biomarkers for Early Detection of Hepatocellular Carcinoma Associated with HCV Infection in Egyptian Patients

Zekri, Abdel-Rahman; Youssef, Amira Salah El-Din; Bakr, Yasser Mabrouk; Gabr, Reham Mohamed; El-Rouby, Mahmoud Nour El-Din; Hammad, Ibtisam; Ahmed, Entsar Abd El-Monaem; Marzouk, Hanan Abd El-Haleem; Nabil, Mohammed Mahmoud; Hamed, Hanan Abd El-Hafez; Aly, Yasser Hamada Ahmed; Zachariah, Khaled S.; Esmat, Gamal

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자료유형: 학술저널

저자정보: Zekri, Abdel-Rahman (Virology and Immunolgy Unit, Cancer Biology Department, National Cancer Institute) Youssef, Amira Salah El-Din (Virology and Immunolgy Unit, Cancer Biology Department, National Cancer Institute) Bakr, Yasser Mabrouk (Virology and Immunolgy Unit, Cancer Biology Department, National Cancer Institute) Gabr, Reham Mohamed (Virology and Immunolgy Unit, Cancer Biology Department, National Cancer Institute) El-Rouby, Mahmoud Nour El-Din (Virology and Immunolgy Unit, Cancer Biology Department, National Cancer Institute) Hammad, Ibtisam (Botany and Microbiology Department, Faculty of Science, Helwan University) Ahmed, Entsar Abd El-Monaem (Botany and Microbiology Department, Faculty of Science, Helwan University) Marzouk, Hanan Abd El-Haleem (Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University) Nabil, Mohammed Mahmoud (Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University) Hamed, Hanan Abd El-Hafez (Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University) Aly, Yasser Hamada Ahmed (Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University) Zachariah, Khaled S. (Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo Univer) Esmat, Gamal

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 1,281 - 1,287 (7page)

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Background: Early detection of hepatocellular carcinoma using serological markers with better sensitivity and specificity than alpha fetoprotein (AFP) is needed. Aims: The aim of this study was to evaluate the diagnostic value of serum sICAM-1, ${\beta}$-catenin, IL-8, proteasome and sTNFR-II in early detection of HCC. Materials and Methods: Serum levels of IL-8, sICAM-1, sTNFR-II, proteasome and ${\beta}$-catenin were measured by ELISA assay in 479 serum samples from 192 patients with HCC, 96 patients with liver cirrhosis (LC), 96 patients with chronic hepatitis C (CHC) and 95 healthy controls. Results: Serum levels of proteasome, sICAM-1, ${\beta}$-catenin and ${\alpha}FP$ were significantly elevated in HCC group compared to other groups (P-value<0.001), where serum level of IL-8 was significantly elevated in the LC and HCC groups compared to CHC and control groups (P-value <0.001), while no significant difference was noticed in patients with HCC and LC (P-value=0.09). Serum level of sTNFR-II was significantly elevated in patients with LC compared to HCC, CHC and control groups (P-value <0.001); also it was significantly higher in HCC compared to CHC and control groups (P-value <0.001). ROC curve analysis of the studied markers between HCC and other groups revealed that the serum level of proteasome had sensitivity of 75.9% and specificity of 73.4% at a cut-off value of $0.32{\mu}g/ml$ with AUC 0.803 sICAM-1 at cut off value of 778ng/ml, the sensitivity was 75.8% and the specificity was 71.8% with AUC 0.776. ${\beta}$-catenin had sensitivity and specificity of 70% and 68.6% respectively at a cut off value of 8.75ng/ml with an AUC of 0.729. sTNFR-II showed sensitivity of 86.3% and specificity of 51.8% at a cut off value of 6239.5pg/ml with an AUC of 0.722. IL-8 had sensitivity of 70.4% and specificity of 52.3% at a cut off value of 51.5pg/ml with AUC 0.631. Conclusions: Our data supported the role of proteasome, sICAM-1, sTNFR-II and ${\beta}$-catenin in early detection of HCC. Also, using this panel of serological markers in combination with ${\alpha}FP$ may offer improved diagnostic performance over ${\alpha}FP$ alone in the early detection of HCC.

#Hepatocellular carcinoma #${alpha}FP$ #sICAM-1 #proteasome #${beta}$-catenin #IL-8 #sTNFR-II

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