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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Min Ho (Department of Neurosurgery, Spine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Sun-Ho (Department of Neurosurgery, Spine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Kim, Eun-Sang (Department of Neurosurgery, Spine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Eoh, Whan (Department of Neurosurgery, Spine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Chung, Sung-Soo (Department of Orthopedic Surgery, Spine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Chong-Suh (Department of Orthopedic Surgery, Spine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제58권 제5호
발행연도
2015.1
수록면
448 - 453 (6page)

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Objective : Recently, the survival of patients with hepatocellular carcinoma (HCC) has been prolonged with improvements in various diagnostic tools and medical treatment modalities. Consequently, spine metastases from HCC are being diagnosed more frequently. The accurate prediction of prognosis plays a critical role in determining a patient's treatment plan, including surgery for patients with spinal metastases of HCC. We investigated the clinical features, surgical outcomes, and prognostic factors of HCC presenting with spine metastases, in patients who underwent surgery. Methods : A retrospective review was conducted on 33 HCC patients who underwent 36 operations (three patients underwent surgical treatment twice) from February 2006 to December 2013. The median age of the patients was 56 years old (range, 28 to 71; male : female=30 : 3). Results : Overall survival was not correlated with age, sex, level of metastases, preoperative Child-Pugh classification, preoperative ambulatory function, preoperative radiotherapy, type of operation, administration of Sorafenib, or the Tokuhashi scoring system. Only the Tomita scoring system was shown to be an independent prognostic factor for overall survival. Comparing the Child-Pugh classification and ambulatory ability, there were no statistically differences between patients pre- and post-operatively. Conclusion : The Tomita scoring system represents a practicable and highly predictive prognostic tool. Even though surgical intervention may not restore ambulatory function, it should be considered to prevent deterioration of the patient's overall condition. Additionally, aggressive management may be needed if there is any ambulatory ability remaining.
#Spinal metastasis #Hepatocellular carcinoma #Prognostic factor

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참고문헌 (36)

참고문헌 신청
Abrahm JL. / 2008 / Spinal cord compression in patients with advanced metastatic cancer : "all I care about is walking and living my life" / JAMA 299:937~946 google schola Bilsky MH. / 2009 / Shifting paradigms in the treatment of metastatic spine disease. Spine(Phila Pa 1976) / Spine (Phila Pa 1976) 34:S101~S107 google schola Chang EL. / 2007 / Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure / J Neurosurg Spine 7:151~160 google schola Chang UK. / 2014 / Clinical result of stereotactic radiosurgery for spinal metastasis from hepatocellular carcinoma : comparison with conventional radiation therapy / J Neurooncol 119:141~148 google schola Chao ST. / 2012 / Recursive partitioning analysis index is predictive for overall survival in patients undergoing spine stereotactic body radiation therapy for spinal metastases / Int J Radiat Oncol Biol Phys 82:1738~1743 google schola

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