Noni Inhibits Neuronal Damage Caused by the Immune Reaction of Microglial Cells Activated by Doxorubicin

Se-Hwa Jung; Seong-Min Lee; Ji-Sun Ha; 양승주; Pyung-Hwan Kim

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자료유형: 학술저널

저자정보: Se-Hwa Jung (Department of Biomedical Laboratory Science Konyang University Daejeon Korea) Seong-Min Lee (Department of Biomedical Laboratory Science Konyang University Daejeon Korea) Ji-Sun Ha (Department of Biomedical Laboratory Science Konyang University Daejeon Korea) 양승주 (Department of Biomedical Laboratory Science Konyang University Daejeon Korea) Pyung-Hwan Kim (Department of Biomedical Laboratory Science Konyang University Daejeon Korea)

저널정보: 대한임상검사과학회 대한임상검사과학회지 대한임상검사과학회지 제52권 제4호

발행연도: 2020.1

수록면: 389 - 397 (9page)

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Microglial cells function as major immune cells in the brain, playing an important role in the protection and damage of neurons. BV2 microglia, activated by drug stimulation, secrete inflammatory cytokines by activating the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway and are involved in neuroinflammatory and immune responses. The overactivation of microglia by stimuli can cause neuronal damage, leading to brain disease. Noni, a natural product, reduces the activity of microglia to prevent neuronal damage and is a potential natural medicine because it exerts excellent regeneration and anti-inflammatory effects on damaged cells. In this study, when noni was used to treat BV2 cells stimulated by the anti-cancer drug doxorubicin, it reduced the release of pro-inflammatory cytokines from BV2. On the other hand, neuronal damage is a side effect of doxorubicin. Therefore, the cytokines released from doxorubicin-stimulated BV2 cells treated with noni had a positive effect on the neuronal viability compared to those released from doxorubicin-stimulated BV2 cells not treated with Noni. Thus, Noni increases neuronal viability. These results suggest that noni inhibits the release of cytokines by regulating the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway of BV2, thereby inhibiting neuronal damage.

#Activated #BV-2 microglia #Doxorubicin #Neuron #Noni

참고문헌 (25)

참고문헌 신청

Hiroyoshi Mori / 2010 / Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Doxorubicin-Induced Cardiomyopathy in Mice / Circulation Journal 74(6):1183~1190

Jae-Won Lee / 2011 / Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated from Rhus verniciflua in LPS-stimulated BV2 Microglial Cells / The Korean Journal of Physiology & Pharmacology 15(1):9~15

L. Bigotte / 1987 / Degeneration of trigeminal ganglion neurons caused by retrograde axonal transport of doxorubicin / Neurology 37(6):985~985

Sara Emad El-Agamy / 2018 / Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries / Molecular Neurobiology 55(7):5727~5740

Yevheniia Hurmach / 2020 / C60 fullerene governs doxorubicin effect on metabolic profile of rat microglial cells in vitro / Molecular Pharmaceutics 17(9):3622~3632

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