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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제10호
- 발행연도
- 2017.1
- 수록면
- 1,827 - 1,836 (10page)
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The world dairy industry has long been challenged by bovine mastitis, an inflammatory disease, which causes economic loss due to decreased milk production and quality. Attempts have been made to prevent or treat this disease with multiple approaches, primarily through increased abuse of antibiotics, but effective natural solutions remain elusive. Bee venom (BV) contains a variety of peptides (e.g., melittin) and shows multiple bioactivities, including prevention of inflammation. Thus, in the current study, it was hypothesized that BV can reduce inflammation in bovine mammary epithelial cells (MAC-T). To examine the hypothesis, cells were treated with LPS (1 μg/ml) to induce an inflammatory response and the antiinflammatory effects of BV (2.5 and 5 μg/ml) were investigated. The cellular mechanisms of BV against LPS-induced inflammation were also investigated. Results showed that BV can attenuate expression of an inflammatory protein, COX2, and pro-inflammatory cytokines such as IL-6 and TNF-α. Activation of NF-κB, an inflammatory transcription factor, was significantly downregulated by BV in cells treated with LPS, through dephosphorylation of ERK1/2. Moreover, pretreatment of cells with BV attenuated LPS-induced production of intracellular reactive oxygen species (e.g., superoxide anion). These results support our hypothesis that BV can decrease LPS-induced inflammatory responses in bovine mammary epithelial cells through inhibition of oxidative stress, NF-κB, ERK1/2, and COX-2 signaling.
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참고문헌 (21)
참고문헌 신청
Bougarn S / 2011 / Technical note: validation of candidate reference genes for normalization of quantitative PCR in bovine mammary epithelial cells responding to inflammatory
Contreras GA / 2011 / Mastitis: comparative etiology and epidemiology / J. Mammary Gland Biol. Neoplasia 16 : 339 ~ 356
Gomes FI / 2016 / Antimicrobial potential of Eucalyptus globulus against biofilms of Staphylococcus aureus isolated from bovine mastitis / Preceedings of Biofilms 7 Conference 201
Han S / 2009 / Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus / J. Asian Nat. Prod. Res 1
Han SG / 2013 / Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells / Toxicology 306 : 1 ~ 8
Contreras GA / 2011 / Mastitis: comparative etiology and epidemiology / J. Mammary Gland Biol. Neoplasia 16 : 339 ~ 356
Gomes FI / 2016 / Antimicrobial potential of Eucalyptus globulus against biofilms of Staphylococcus aureus isolated from bovine mastitis / Preceedings of Biofilms 7 Conference 201
Han S / 2009 / Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus / J. Asian Nat. Prod. Res 1
Han SG / 2013 / Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells / Toxicology 306 : 1 ~ 8
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