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논문 기본 정보

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Benetti Francine (Department of Restorative Dentistry Universidade Federal de Minas Gerais (UFMG) School of Dentistry) Gomes-Filho Joao Eduardo (Department of Preventive and Restorative Dentistry Sao Paulo State University (UNESP) School of Den) de Azevedo-Queiroz India Olinta (Department of Preventive and Restorative Dentistry Sao Paulo State University (UNESP) School of Den) Carminatti Marina (Department of Preventive and Restorative Dentistry Sao Paulo State University (UNESP) School of Den) Conti Leticia Citelli (Department of Preventive and Restorative Dentistry Sao Paulo State University (UNESP) School of Den) dos Reis-Prado Alexandre Henrique (Department of Restorative Dentistry Universidade Federal de Minas Gerais (UFMG) School of Dentistry) de Oliveira Sandra Helena Penha (Department of Basic Science Sao Paulo State University (UNESP) School of Dentistry Aracatuba SP Bra) Ervolino Edilson (Department of Basic Science Sao Paulo State University (UNESP) School of Dentistry Aracatuba SP Bra) Dezan-Junior Eloi (Department of Preventive and Restorative Dentistry Sao Paulo State University (UNESP) School of Den) Cintra Luciano Tavares Angelo (Department of Preventive and Restorative Dentistry Sao Paulo State University (UNESP) School of Den)
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대한치과보존학회 Restorative Dentistry and Endodontics Restorative Dentistry and Endodontics 제46권 제2호
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2021.1
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Objectives This study compared the cytotoxicity, biocompatibility, and tenascin immunolabeling of a new ready-to-use hydraulic sealer (Bio-C Sealer) with MTA-Fillapex and white MTA-Angelus. Materials and Methods L929 fibroblasts were cultivated and exposed to undiluted and diluted material extracts. Polyethylene tubes with or without (the control) the materials were implanted into the dorsa of rats. At 7 days and 30 days, the rats were euthanized, and the specimens were prepared for analysis; inflammation and immunolabeling were measured, and statistical analysis was performed (p < 0.05). Results MTA-Fillapex exhibited greater cytotoxicity than the other materials at all time points (p < 0.05). The undiluted Bio-C Sealer exhibited greater cytocompatibility at 6 and 48 hours than white MTA-Angelus, with higher cell viability than in the control (p < 0.05). White MTA-Angelus displayed higher cell viability than the control at 24 hours, and the one-half dilution displayed similar results at both 6 and 48 hours (p < 0.05). At 7 days and 30 days, the groups exhibited moderate inflammation with thick fibrous capsules and mild inflammation with thin fibrous capsules, respectively (p > 0.05). At 7 days, moderate to strong immunolabeling was observed (p > 0.05). After 30 days, the control and MTA-Fillapex groups exhibited strong immunolabeling, the white MTA-Angelus group exhibited moderate immunolabeling (p > 0.05), and the Bio-C Sealer group exhibited low-to-moderate immunolabeling, differing significantly from the control (p < 0.05). Conclusions Bio-C Sealer and white MTA-Angelus exhibited greater cytocompatibility than MTA-Fillapex; all materials displayed adequate biocompatibility and induced tenascin immunolabeling.
#Biocompatibility #Cytotoxicity #Hydraulic sealer #Mineral trioxide aggregate #Tenascin

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참고문헌 (44)

참고문헌 신청
Vouzara T / 2018 / Cytotoxicity of a new calcium silicate endodontic sealer / J Endod 44:849~852 google schola Shie MY / 2012 / Effects of altering the Si/Ca molar ratio of a calcium silicate cement on in vitro cell attachment / Int Endod J 45:337~345 google schola Saghiri MA / 2017 / Calcium silicate-based cements and functional impacts of various constituents / Dent Mater J 36:8~18 google schola Han L / 2011 / Uptake of calcium and silicon released from calcium silicate-based endodontic materials into root canal dentine / Int Endod J 44:1081~1087 google schola Reyes-Carmona JF / 2010 / The biomineralization ability of mineral trioxide aggregate and Portland cement on dentin enhances the push-out strength / J Endod 36:286~291 google schola

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