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학술저널
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Hoshino Roberto Alameda (Department of Restorative Dentistry Dental School Sao Paulo State University (UNESP) Araraquara SP) Delfino Mateus Machado (Department of Restorative Dentistry Dental School Sao Paulo State University (UNESP) Araraquara SP) da Silva Guilherme Ferreira (Pro-Rectory of Research and Post-graduation School of Dentistry Universidade Sagrado Coracao (USC)) Guerreiro-Tanomaru Juliane Maria (Department of Restorative Dentistry Dental School Sao Paulo State University (UNESP) Araraquara SP) Tanomaru-Filho Mario (Department of Restorative Dentistry Dental School Sao Paulo State University (UNESP) Araraquara SP) Sasso-Cerri Estela (Department of Morphology Genetics Orthodontics and Pediatric Dentistry Laboratory of Histology and) Cerri Paulo Sergio (Department of Morphology Genetics Orthodontics and Pediatric Dentistry Laboratory of Histology and)
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대한치과보존학회 Restorative Dentistry and Endodontics Restorative Dentistry and Endodontics 제46권 제1호
발행연도
2021.1
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Objectives This study evaluated the biocompatibility and bioactive potential of NeoMTA Plus mixed as a root canal sealer in comparison with MTA Fillapex. Materials and Methods Polyethylene tubes filled with NeoMTA Plus (n = 20), MTA Fillapex (n = 20), or nothing (control group, CG; n = 20) were inserted into the connective tissue in the dorsal subcutaneous layer of rats. After 7, 15, 30 and 60 days, the specimens were processed for paraffin embedding. The capsule thickness, collagen content, and number of inflammatory cells (ICs) and interleukin-6 (IL-6) immunolabeled cells were measured. von Kossa-positive structures were evaluated and unstained sections were analyzed under polarized light. Two-way analysis of variance was performed, followed by the post hoc Tukey test (p ≤ 0.05). Results At 7 days, the capsules around NeoMTA Plus and MTA Fillapex had more ICs and IL-6-immunostained cells than the CG. However, at 60 days, there was no significant difference in the IC number between NeoMTA Plus and the CG (p = 0.1137) or the MTA Fillapex group (p = 0.4062), although a greater number of IL-6-immunostained cells was observed in the MTA Fillapex group (p = 0.0353). From 7 to 60 days, the capsule thickness of the NeoMTA Plus and MTA Fillapex specimens significantly decreased, concomitantly with an increase in the collagen content. The capsules around root canal sealers showed positivity to the von Kossa stain and birefringent structures. Conclusions The NeoMTA Plus root canal sealer is biocompatible and exhibits bioactive potential.

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