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논문 기본 정보

자료유형
학술저널
저자정보
Jung-Jin Kim (The Catholic University of Korea) 배치운 (가톨릭대학교) Changsu Han (Korea University) Won-Myong Bahk (The Catholic University of Korea) Soo-Jung Lee (The Catholic University of Korea) Ashwin A. Patkar (Rush University) Prakash S. Masand (Global Medical Education)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제4호
발행연도
2021.11
수록면
600 - 609 (10page)
DOI
10.9758/cpn.2021.19.4.600

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The mainstay of schizophrenia treatment is pharmacological therapy using various antipsychotics including first- and second-generation antipsychotics which have different pharmacokinetic and pharmacodynamic property leading to differential presentation of adverse events (AEs) and treatment effects such as negative symptoms, cognitive symptoms and cormorbid symptoms. Major treatment guidelines suggest the use of antipsychotic monotherapy (APM) as a gold standard in the treatment of schizophrenia. However, the effects of APM is inadequate and less potent to achieve symptom remission as well as functional recovery in real practice which has been consistently reported in numerous controlled clinical trials, large practical trials, independent small studies and systematic reviews till today. Therefore antipsychotic polypharmacy (APP) regardless of the class of antipsychotics has been also commonly utilized for many reasons in real world practice. However, APP has also crucial pitfalls including increase of total psychotics including antipsychotics, high-doses of antipsychotics used, poor compliance, drug-drug interaction and risks for developing AEs, all of which are paradoxically related to poor clinical outcomes, whereas APP has also substantial advantages in reduction of re-hospitalization, severe psychopathology and targeted control of concurrent symptoms. Given currently limited therapeutic options, it is also important to properly utilize APP in order to maximize its clinical utility and minimize its risk for better treatment outcomes for patients with schizophrenia, based on risk/benefit with full understanding of pharmacological and clinical issues on APP. The present paper intends to address intriguing and important issues in the use of APP in real world practice.
#Antipsychotics #Schizophrenia #Polypharmacy #Issue.

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참고문헌 (65)

참고문헌 신청
Psychosis and schizophrenia in adults: prevention and management google schola Jung Suk Lee / 2020 / Korean Medication Algorithm for Schizophrenia 2019, Second Revision: Treatment of Psychotic Symptoms / Clinical Psychopharmacology and Neuroscience 18(3):386~394 dbpia Hasan A / 2012 / World Federation of Societies of Biological Psychiatry(WFSBP)Guidelines for Biological Treatment of Schizophrenia, part 1 : update 2012 on the acute treatment of schizophrenia and the management of treatment resistance / World J Biol Psychiatry 13:318~378 google schola Barnes TR / 2020 / Evidence-based guidelines for the pharmacological treatment of schizophrenia : updated recommendations from the British Association for Psychopharmacology / J Psychopharmacol 34:3~78 google schola Galletly C / 2016 / Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders / Aust N Z J Psychiatry 50:410~472 google schola

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