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A Study on Discontinuation Rate on Maintenance Treatment of Antipsychotic Agents in Schizophrenic Patients
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조현병 환자에서 항정신병약물 유지치료 시 치료결과에 대한 연구

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Type
Academic journal
Author
배하현 (국립정신건강센터) 나의현 (가톨릭대학교) 윤해주 (국립정신건강센터) PARK EUNKYOUNG (삼성서울병원) 이종일 (국립정신건강센터)
Journal
대한조현병학회 대한조현병학회지 대한조현병학회지 제20권 제2호 KCI Accredited Journals
Published
2017.10
Pages
69 - 76 (8page)

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A Study on Discontinuation Rate on Maintenance Treatment of Antipsychotic Agents in Schizophrenic Patients
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Objectives : Relapse prevention is a major therapeutic goal in the treatment of schizophrenia. However, many patients experience multiple functional impairments and treatment resistance due to recurrence. This study was designed to investigate the follow-up of patients with using antipsychotic drugs and to compare the total treatment failure rate, withdrawal reasons, and duration period of antipsychotic drugs. Methods :IThe subjects were 1963 patients who taking antipsychotic drugs under the diagnosis of schizophrenia. We selected 1836 patients using 10 antipsychotic drugs according to frequency of using. The rate of total treatment failure of them was divided into 6-month, 1-year, 2-year, 3-year, and 5-year according to the time of drug withdrawal. We compared the total treatment failure rate at 1 and 3-year between 10 antipsychotic drugs. Results : The total treatment failure rate of clozapine was lowest compared with the other 9 antipsychotic drugs in all the surveyed periods. When evaluating actual number of subjects, olanzapine, sulpiride, risperidone, aripiprazole, amisulpride, and haloperidol were lower significantly compared with ziprasidone at 1-year in the total treatment failure rate, but there was no significant difference between them except clozapine at 3-year. The results of the analysis based on the number of prescriptions showed that the total treatment failure rate of the atypical antipsychotic drug was lower than that of the typical antipsychotic drug at 1-year, but the difference was decreased over time except quetiapine and ziprasidone. Conclusion : In conclusion, although there is some controversy about which drug to prescribe to the patient, the clinician needs a proper prescription considering various factors such as efficacy, side effects, price, and formulations of each drug.
#Schizophrenia · Antipsychotic drugs · Total treatment failure

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References (21)

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Pincus HA / 2010 / From PORT to policy to patient outcomes: crossing the quality chasm / Schizophr Bull 36:109~111 google schola Huang SS / 2013 / Antipsychotic formulation and one-year rehospitalization of schizophrenia patients: a population-based cohort study / Psychiatr Serv 64:1259~1262 google schola Gitlin M / 2001 / Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia / Am J Psychiatry 158:1835~1842 google schola Kane JM / 2009 / A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia / J Clin Psychiatry 70:572~581 google schola Stroup TS / 2006 / Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic / Am J Psychiatry 163:611~622 google schola

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