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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제6호
- 발행연도
- 2020.1
- 수록면
- 473 - 479 (7page)
이용수
초록· 키워드
오류제보하기
Endothelial cell injury is a major contributor to cardiovascular diseases. The 2,3,5,4’-Tetrahydroxystilbene-2-O-?-D-Glucoside (TSG) contributes to alleviate human umbilical vein endothelial cells (HUVECs) injury through mechanisms still know a little. This study aims to clarify the TSG effects on gene expression (mRNA and microRNA) related to oxidative stress and endoplasmic reticulum stress induced by H2O2 in HUVECs. We found that TSG significantly reduced the death rate of cells and increased intracellular superoxide dismutase activity. At qRT-PCR, experimental data showed that TSG significantly counteracted the expressions of miR-9-5p, miR-16, miR-21, miR-29b, miR-145-5p, and miR-204-5p. Besides, TSG prevented the expression of ATF6 and CHOP increasing. In contrast, TSG promoted the expression of E2F1. In conclusion, our results point to the obvious protective effect of TSG on HUVECs injury induced by H2O2, and the mechanism may through miR16/ATF6/ E2F1 signaling pathway
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ueda P / 2017 / Laboratory-based and office-based risk scores and charts to predict 10-year risk of cardiovascular disease in 182 countries : a pooled analysis of prospective cohorts and health surveys / Lancet Diabetes Endocrinol 5:196~213
Scioli MG / 2020 / Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction : potential diagnostic biomarkers and therapeutic targets / J Clin Med 9:1995
Wu Q / 2018 / Protective effect of Polygonum orientale flower extract on H2O2-induced oxidative damage of HUVEC cells / Zhongguo Zhong Yao Za Zhi 43:1008~1013
Büchter C / 2015 / TSG(2, 3, 5, 4'-Tetrahydroxystilbene-2-O-β-D-glucoside)from the Chinese herb Polygonum multiflorum increases life span and stress resistance of Caenorhabditis elegans / Oxid Med Cell Longev 2015:124357
Zhao J / 2016 / TSG attenuates LPC-induced endothelial cells inflammatory damage through notch signaling inhibition / IUBMB Life 68:37~50
Scioli MG / 2020 / Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction : potential diagnostic biomarkers and therapeutic targets / J Clin Med 9:1995
Wu Q / 2018 / Protective effect of Polygonum orientale flower extract on H2O2-induced oxidative damage of HUVEC cells / Zhongguo Zhong Yao Za Zhi 43:1008~1013
Büchter C / 2015 / TSG(2, 3, 5, 4'-Tetrahydroxystilbene-2-O-β-D-glucoside)from the Chinese herb Polygonum multiflorum increases life span and stress resistance of Caenorhabditis elegans / Oxid Med Cell Longev 2015:124357
Zhao J / 2016 / TSG attenuates LPC-induced endothelial cells inflammatory damage through notch signaling inhibition / IUBMB Life 68:37~50
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