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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제5호
- 발행연도
- 2020.1
- 수록면
- 413 - 422 (10page)
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Delphinidin is a major anthocyanidin compound found in various vegetables and fruits. It has anti-oxidant, anti-inflammatory, and various other biological activities. In this study we demonstrated the anti-cancer activity of delphinidin, which was related to autophagy, in radiation-exposed non-small cell lung cancer (NSCLC). Radiosensitising effects were assessed in vitro by treating cells with a subcytotoxic dose of delphinidin (5 ?M) before exposure to ?-ionising radiation (IR). We found that treatment with delphinidin or IR induced NSCLC cell death in vitro; however the combination of delphinidin pre-treatment and IR was more effective than either agent alone, yielding a radiation enhancement ratio of 1.54 at the 50% lethal dose. Moreover, combined treatment with delphinidin and IR, enhanced apoptotic cell death, suppressed the mTOR pathway, and activated the JNK/MAPK pathway. Delphinidin inhibited the phosphorylation of PI3K, AKT, and mTOR, and increased the expression of autophagy-induced cell death associated-protein in radiation-exposed NSCLC cells. In addition, JNK phosphorylation was upregulated by delphinidin pre-treatment in radiation-exposed NSCLC cells. Collectively, these results show that delphinidin acts as a radiation-sensitizing agent through autophagy induction and JNK/MAPK pathway activation, thus enhancing apoptotic cell death in NSCLC cells.
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참고문헌 (49)
참고문헌 신청
Tsuyuki S / 2012 / Delphinidin induces autolysosome as well as autophagosome formation and delphinidin-induced autophagy exerts a cell protective role / J Biochem Mol Toxicol 26:445~453
Wang H / 1999 / Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries / J Nat Prod 62:294~296
Ji-Young Lee / 2016 / Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice / Nutrition Research and Practice 10(5):494~500
Kasten-Pisula U / 2007 / Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis / Radiother Oncol 83:296~303
Bump EA / 2003 / Burger's medicinal chemistry and drug discovery / Wiley :151~214
Wang H / 1999 / Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries / J Nat Prod 62:294~296
Ji-Young Lee / 2016 / Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice / Nutrition Research and Practice 10(5):494~500
Kasten-Pisula U / 2007 / Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis / Radiother Oncol 83:296~303
Bump EA / 2003 / Burger's medicinal chemistry and drug discovery / Wiley :151~214
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