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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 74 - 80 (7page)
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초록· 키워드
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Autophagy is an evolutionarily well-conserved cellular homeostasis program that responds to various cellular stresses and degrades unnecessary or harmful intracellular materials in lysosomes. Accumulating evidence has shown that autophagy dysfunction often results in various human pathophysiological conditions, including metabolic disorders, cancers, and neurodegenerative diseases. The discovery of an autophagy machinery protein network has revealed underlying molecular mechanisms of autophagy, and advances in the understanding of its regulatory mechanism have provided novel therapeutic targets for treating human diseases. Recently, reports have emerged on the involvement of autophagy in oral squamous cell carcinoma (OSCC). Although the role of autophagy in cancer therapy is controversial, the beneficial use of the induction of autophagic cell death in OSCC has drawn significant attention. In this review, the types of autophagy, mechanism of autophagosome biogenesis, and modulating molecules and therapeutic candidates affecting the induction of autophagic cell death in OSCC are briefly described. type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the effect of vinpocetine on the proliferation of colon cancer cells and its underlying molecular mechanisms. Our data showed that vinpocetine inhibits the viability and proliferation of colon cancer cells. Vinpocetine treatment induced cell death in HCT116 cells, which the percentages of sub-G1 phase were significantly increased, and the apoptosis-related genes were regulated after HCT116 cells were treated with vinpocetine. In sum, our findings indicated that vinpocetine could be a therapeutically useful candidate in the treatment of colon cancer.
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참고문헌 (65)
참고문헌 신청
Klionsky DJ / 2000 / Autophagy as a regulated pathway of cellular degradation / Science 290:1717~1721
Yang Y / 2020 / Autophagy and disease : unanswered questions / Cell Death Differ 27:858~871
Levine B / 2019 / Biological functions of autophagy genes : a disease perspective / Cell 176:11~42
Choi AM / 2013 / Autophagy in human health and disease / N Engl J Med 368:651~662
Li WW / 2012 / Microautophagy : lesser-known selfeating / Cell Mol Life Sci 69:1125~1136
Yang Y / 2020 / Autophagy and disease : unanswered questions / Cell Death Differ 27:858~871
Levine B / 2019 / Biological functions of autophagy genes : a disease perspective / Cell 176:11~42
Choi AM / 2013 / Autophagy in human health and disease / N Engl J Med 368:651~662
Li WW / 2012 / Microautophagy : lesser-known selfeating / Cell Mol Life Sci 69:1125~1136
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Curcumin-Induced Autophagy Augments Its Antitumor Effect against A172 Human Glioblastoma Cells
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Ginger and its two active components as novel autophagic and apoptotic mediators in oral squamous cell carcinoma
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Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells
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De novo design of a novel AIE fluorescent probe tailored to autophagy visualization via pH manipulation
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Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells
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Chracterization of THP-1 Cell Death Induced by Porphyromonas gingivalis Infection
International Journal of Oral Biology
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Luteolin inhibits proliferation, induces apoptosis and autophagy, and regulates MAPK pathways in human oral cancer cell lines
한국실험동물학회 학술발표대회 논문집
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