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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Delphinidin possesses strong anti-oxidant, anti-inflammatory, and anti-cancer properties. Suppression of the Wnt/β-catenin signaling pathway is a potential strategy for chemoprevention and therapy. As aberrant activation of the β-catenin signaling pathway contributes to prostate cancer progression, we evaluated the effect of delphinidin on this pathway in human PC3 prostate cancer cells. An MTT assay showed that treatment with delphinidin (15-180 μM, 72 hours) resulted in a dose-dependent growth inhibition of cells. Treatment with delphinidin increased the phosphorylation of serine or threonine residues on β-catenin and decreased the levels of cytoplasmic β-catenin. Moreover, treatment with delphinidin inhibited the nuclear translocation of β-catenin and the expression of β-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1. Delphinidin also induced the phosphorylation of glycogen synthase kinase 3β and the expression of adenomatous polyposis coli and Axin proteins. Our results indicate that inhibition of cell growth by delphinidin is mediated, at least in part, through modulation of the β-catenin signaling pathway. We suggest that delphinidin is a potent inhibitor of Wnt/β-catenin signaling in prostate cancer cells. (J Cancer Prev 2016;21:110-114)
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참고문헌 (14)
참고문헌 신청
Ting H / 2014 / The strategies to control prostate cancer by chemoprevention approaches / Mutat Res 760:1~15
Traka MH / 2014 / Sulforaphane and prostate cancer interception / Drug Discov Today 19:1488~1492
Surh YJ / 2003 / Cancer chemoprevention with dietary phytochemicals / Nat Rev Cancer 3:768~780
Takahashi-Yanaga F / 2007 / The Wnt/beta-catenin signaling pathway as a target in drug discovery / J Pharmacol Sci 104:293~302
Tarapore RS / 2012 / Modulation of Wnt/β-catenin signaling pathway by bioactive food components / Carcinogenesis 33:483~491
Traka MH / 2014 / Sulforaphane and prostate cancer interception / Drug Discov Today 19:1488~1492
Surh YJ / 2003 / Cancer chemoprevention with dietary phytochemicals / Nat Rev Cancer 3:768~780
Takahashi-Yanaga F / 2007 / The Wnt/beta-catenin signaling pathway as a target in drug discovery / J Pharmacol Sci 104:293~302
Tarapore RS / 2012 / Modulation of Wnt/β-catenin signaling pathway by bioactive food components / Carcinogenesis 33:483~491
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