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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 85 - 91 (7page)
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Quercetin is a natural flavonoid phytochemical that is extracted from various plants. Having an advantages due to its varied biological properties, such as anti-inflammatory, anti-viral, anti-oxidant, and anti-cancer effects, quercetin is used to treat many diseases. Recently, it has been reported that autophagy inhibition may play a key role in anti-cancer therapy. Therefore, in this study, we investigated the molecular mechanisms and anti-cancer effects of quercetin in human osteosarcoma cells via autophagy inhibition. We ascertained that quercetin inhibited cell proliferation and induced cell death, these process is demonstrated that apoptosis via the mitochondrial pathway and the caspase cascade. Quercetin also induced autophagy which was inhibited by 3-MA, autophagy inhibitor and the blockade of autophagy promoted the quercetin-induced apoptosis, confirming that autophagy is a pro-survival process. Thus, these findings demonstrate that quercetin is an effective anti-cancer agent, and the combination of quercetin and an autophagy inhibitor should enhance the effect of anti-cancer therapy.
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참고문헌 (23)
참고문헌 신청
Annick Notte / 2011 / Autophagy as a mediator of chemotherapy-induced cell death in cancer / Biochemical Pharmacology 82 (5) : 427 ~ 434
Bo-Lin Chen / 2014 / Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway / The Journal of Nut
Broadhead ML / 2011 / The molecular pathogenesis of osteosarcoma: a review / Sarcoma 2011 : 959248 ~
Dominique Heymann / 2013 / Targeted therapies for bone sarcomas / BoneKEy Reports 2
E. Sugantha Priya / 2014 / Anti-cancer activity of quercetin in neuroblastoma: an in vitro approach / Neurological Sciences 35 (2) : 163 ~ 170
Bo-Lin Chen / 2014 / Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway / The Journal of Nut
Broadhead ML / 2011 / The molecular pathogenesis of osteosarcoma: a review / Sarcoma 2011 : 959248 ~
Dominique Heymann / 2013 / Targeted therapies for bone sarcomas / BoneKEy Reports 2
E. Sugantha Priya / 2014 / Anti-cancer activity of quercetin in neuroblastoma: an in vitro approach / Neurological Sciences 35 (2) : 163 ~ 170
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Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
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Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells
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Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents
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Autophagy in Tumorigenesis and Cancer Treatment
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2015 .01
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Preventive and Therapeutic Effects of Quercetin on Experimental Radiation Induced Lung Injury in Mice
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Non-small-cell Lung-cancer Cell Line, A549
Journal of Pharmacopuncture
2015 .01
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HepG2 cell에서 quercetin의 HO-1 발현을 통한 mitochondria의 생합성 유도 효과에 관한 연구
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Autophagy in the placenta
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Can Cancer Therapy be Achieved by Bridging Apoptosis and Autophagy: a Method Based on microRNA-Dependent Gene Therapy and Phytochemical Targets
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Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells
Cancer Research and Treatment
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Effect of proton beam irradiation on cytotoxicity and anti-inflammatory activity of quercetin
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Anti-Cancer Natural Products Inducing Cross-talk between Apoptosis and Autophagy Mutual Proteins to Regulate Cancer Cell Death: Design of Future Green Anticancer Therapies
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Autophagy and its regulation by ginseng components
Journal of Ginseng Research
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Quercetin protects neuronal cells against focal cerebral ischemia and glutamate-induced damage via inhibition of apoptotic pathway
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Luteolin inhibits proliferation, induces apoptosis and autophagy, and regulates MAPK pathways in human oral cancer cell lines
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Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells
Journal of Ginseng Research
2017 .07
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Autophagy: a lysosomal degradation process for cellular homeostasis and its relationship with oral squamous cell carcinoma
International Journal of Oral Biology
2021 .01
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Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
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Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model and HT-22 cells
한국실험동물학회 학술발표대회 논문집
2018 .07
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Role of Autophagy in the Pathogenesis of Diabetes and Therapeutic Potential of Autophagy Modulators in the Treatment of Diabetes and Metabolic Syndrome
Journal of Korean Medical Science
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