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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 162 - 171 (10page)
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Purpose The clinical implications of tumor-infiltrating T cell subsets and their spatial distribution in biliary tract cancer (BTC) patients treated with gemcitabine plus cisplatin were investigated. Materials and Methods A total of 52 BTC patients treated with palliative gemcitabine plus cisplatin were included. Multiplexed immunohistochemistry was performed on tumor tissues, and immune infiltrates were separately analyzed for the stroma, tumor margin, and tumor core. Results The density of CD8+ T cells, FoxP3? CD4+ helper T cells, and FoxP3+ CD4+ regulatory T cells was significantly higher in the tumor margin than in the stroma and tumor core. The density of LAG3? or TIM3-expressing CD8+ T cell and FoxP3? CD4+ helper T cell infiltrates was also higher in the tumor margin. In extrahepatic cholangiocarcinoma, there was a higher density of T cell subsets in the tumor core and regulatory T cells in all regions. A high density of FoxP3? CD4+ helper T cells in the tumor margin showed a trend toward better progression-free survival (PFS) (p=0.092) and significantly better overall survival (OS) (p=0.012). In multivariate analyses, a high density of FoxP3? CD4+ helper T cells in the tumor margin was independently associated with favorable PFS and OS. Conclusion The tumor margin is the major site for the active infiltration of T cell subsets with higher levels of LAG3 and TIM3 expression in BTC. The density of tumor margin-infiltrating FoxP3? CD4+ helper T cells may be associated with clinical outcomes in BTC patients treated with gemcitabine plus cisplatin.
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참고문헌 (30)
참고문헌 신청
Valle J / 2010 / Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer / N Engl J Med 362:1273~1281
Chae H / 2019 / Therapeutic relevance of targeted sequencing in management of patients with advanced biliary tract cancer : DNA damage repair gene mutations as a predictive biomarker / Eur J Cancer 120:31~39
Abou-Alfa GK / 2020 / Ivosidenib in IDH1-mutant, chemotherapyrefractory cholangiocarcinoma(ClarIDHy) : a multicentre, randomised, double-blind, placebo-controlled, phase 3 study / Lancet Oncol 21:796~807
Abou-Alfa GK / 2020 / Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma : a multicentre, open-label, phase 2 study / Lancet Oncol 21:671~684
Yoo C / 2020 / Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1, in patients with pretreated biliary tract cancer / J Immunother Cancer 8:e000564
Chae H / 2019 / Therapeutic relevance of targeted sequencing in management of patients with advanced biliary tract cancer : DNA damage repair gene mutations as a predictive biomarker / Eur J Cancer 120:31~39
Abou-Alfa GK / 2020 / Ivosidenib in IDH1-mutant, chemotherapyrefractory cholangiocarcinoma(ClarIDHy) : a multicentre, randomised, double-blind, placebo-controlled, phase 3 study / Lancet Oncol 21:796~807
Abou-Alfa GK / 2020 / Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma : a multicentre, open-label, phase 2 study / Lancet Oncol 21:671~684
Yoo C / 2020 / Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1, in patients with pretreated biliary tract cancer / J Immunother Cancer 8:e000564
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