지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.3
- 수록면
- 1 - 12 (12page)
- DOI
- https://doi.org/10.3802/jgo.2023.34.e16
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초록· 키워드
오류제보하기
Objective: Surgical management is essential in early-stage vulvar squamous cell carcinoma(SCC), but these surgical procedures often cause significant morbidity. Immunotherapy maybe a new treatment option in these patients. FoxP3+ Tregs suppress anti-tumor immuneresponses. High intratumoral FoxP3+ Treg infiltration has been reported to be associatedwith poor prognosis in most solid tumors. However, there are also conflicting results.
We evaluated FoxP3+ lymphocyte infiltration in vulvar SCC and aimed to determine itsrelationship with prognosis and clinicopathological parameters.
Methods: Cases diagnosed with vulvar SCC in our department were retrospectively reviewed.
The paraffin block that best reflects the morphology was selected, and immunohistochemicalstudies were performed in accordance with the manufacturer’s instructions. FoxP3+lymphocyte counts were made in tumoral stroma and within tumoral cell islands separatelyin hot-spot areas.
Results: We found a positive correlation between high FoxP3+ lymphocyte count and goodprognostic parameters. There was less recurrence in the group with high FoxP3+ lymphocytecounts in tumoral cell islands. Overall sur vival was not statistically different between thesegroups. Less lymphovascular invasion was obser ved in the group with high lymphocyte countin the tumoral stroma.
Conclusion: In vulvar SCC, FoxP3+ Treg infiltration into the tumor stroma and into tumoralcell islands is associated with good prognostic features. In these tumors, stage appeared asthe only independent prognostic parameter. Studies to be conducted in larger series mayreveal whether Tregs can be targeted in cancer treatment.
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