Contrasting Prognostic Effects of Tumor-Infiltrating Lymphocyte Density in Cardia and Non-cardia Gastric Adenocarcinomas

Hyuk-Joon Lee; 김형일; Sang Yong Kim; Jae Eun Yu; Su-Jin Shin; Yun Ho Roh; 정재호; 형우진; 노성훈; Chung-Gyu Park

추천

검색

자료유형: 학술저널

저자정보: Hyuk-Joon Lee 김형일 Sang Yong Kim Jae Eun Yu Su-Jin Shin Yun Ho Roh 정재호 형우진 노성훈 Chung-Gyu Park

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제20권 제2호

발행연도: 2020.1

수록면: 190 - 201 (12page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: This study sought to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in relation to tumor location within the stomach. Materials and Methods: The densities and prognostic significance of TIL subsets were evaluated in 542 gastric cancer patients who underwent gastrectomy. Immunohistochemical staining for CD3, CD4, CD8, forkhead/winged helix transcription factor (Foxp3), and granzyme B was performed. Results: Cardia cancer was associated with significantly lower densities of CD8 T-cells and higher densities of Foxp3 and granzyme B T-cells than non-cardia tumors. Multivariate analysis showed that advanced age (hazard ratio [HR], 1.023; 95% confidence interval [CI], 1.006–1.040), advanced T classification (HR, 2.029; 95% CI, 1.106–3.721), lymph node metastasis (HR, 3.319; 95% CI, 1.947–5.658), low CD3 expression (HR, 0.997; 95% CI, 0.994–0.999), and a high Foxp3/CD4 ratio (HR, 1.007; 95% CI, 1.001–1.012) were independent predictors of poor overall survival in cardia cancer patients. In non-cardia cancer patients, total gastrectomy (HR, 2.147; 95% CI, 1.507–3.059), advanced T classification (HR, 2.158; 95% CI, 1.425–3.266), lymph node metastasis (HR, 1.854; 95% CI, 1.250–2.750), and a low Foxp3/CD4 ratio (HR, 0.978; 95% CI, 0.959–0.997) were poor prognostic factors for survival. Conclusions: The densities and prognostic effects of TILs differed in relation to the location of tumors within the stomach. The contrasting prognostic effects of Foxp3/CD4 ratio in cardia and non-cardia gastric cancer patients suggests that clinicians ought to consider tumor location when determining treatment strategies.

참고문헌 (34)

참고문헌 신청

Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108

Coussens LM / 2002 / Inflammation and cancer / Nature 420:860~867

이승호 / 2017 / Potential Utility of FDG PET-CT as a Non-invasive Tool for Monitoring Local Immune Responses / Journal of Gastric Cancer 17(4):384~393

이지연 / 2015 / Association between Chemotherapy-Response Assays and Subsets of Tumor-Infiltrating Lymphocytes in Gastric Cancer: A Pilot Study / Journal of Gastric Cancer 15(4):223~230

deLeeuw RJ / 2012 / The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer : a critical review of the literature / Clin Cancer Res 18:3022~3029

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!