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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 222 - 226 (5page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThis study aimed to evaluate the total antioxidant activity (TAA) in patients with major depressive disorder (MDD) and the effect of antidepressants on TAA using a novel potentiometric method.
MethodsaaTwenty-eight patients with MDD and thirty-one healthy controls were enrolled in this study. The control group comprised 31 healthy individuals matched for gender, drinking and smoking status. We assessed symptoms of depression using the Hamilton Depression Rating Scale (HAMD) and the Beck Depression Inventory (BDI). We measured TAA using potentiometry. All measurements were made at baseline and four and eight weeks later.
ResultsaaThere was a significant negative correlation between BDI scores and TAA. TAA was significantly lower in the MDD group than in controls. When the MDD group was subdivided into those who showed clinical response to antidepressant therapy (response group) and those who did not (non-response group), only the non-response group showed lower TAA, while the response group showed no significant difference to controls at baseline. After eight weeks of antidepressant treatment, TAA in both the response and non-response groups was similar, and there was no significant difference among the three groups.
ConclusionaaThese results suggest that the response to antidepressant treatment in MDD patients might be predicted by measuring TAA.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Kessler RC / 1997 / The effects of stressful life events on depression / Annu Rev Psychol 48:191~214
Post RM / 1992 / Transduction of psychosocial stress into the neurobiology of recurrent affective disorder / Am J Psychiatry 149:999~1010
Scapagnini G / 2012 / Antioxidants as antidepressants: fact or fiction? / CNS Drugs 26:477~490
Belmaker RH / 2008 / Major depressive disorder / N Engl J Med 358:55~68
Maes M / 2011 / A review on the oxidative and nitrosative stress(O&NS)pathways in major depression and their possible contribution to the(neuro)degenerative processes in that illness / Prog Neuropsychopharmacol Biol Psychiatry 35:676~692
Post RM / 1992 / Transduction of psychosocial stress into the neurobiology of recurrent affective disorder / Am J Psychiatry 149:999~1010
Scapagnini G / 2012 / Antioxidants as antidepressants: fact or fiction? / CNS Drugs 26:477~490
Belmaker RH / 2008 / Major depressive disorder / N Engl J Med 358:55~68
Maes M / 2011 / A review on the oxidative and nitrosative stress(O&NS)pathways in major depression and their possible contribution to the(neuro)degenerative processes in that illness / Prog Neuropsychopharmacol Biol Psychiatry 35:676~692
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