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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 739 - 743 (5page)
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The regulated production of reactive oxygen species (ROS) has been considered a unique property of phagocytic cells which use this ROS system to induce innate defense system that enables it to successfully combat the pathogens. However, the mechanisms for how respiratory mucosa might produce ROS against respiratory viral infection still need to be completely defined. Respiratory mucosa and nasal epithelium has been known as the first defense site of human respiratory tract which is highly exposed and vulnerable to environmental pathogens, including air-bone microbes, viruses and allergens. We are especially interested in the innate immune response to respiratory virus infection in nasal epithelium and how this response might be influenced by ROS generation after viral infection. The interferon (IFN) signaling system is perhaps the most critical pathway for antiviral defense and protective actions of IFNs rely on signaling through IFN receptors, transcription factors and IFN-stimulated genes or antiviral cytokines requiring for virus degradation and suppression of viral transcription or translation. We verified that both type I and type III IFN genes expression and secreted proteins were more highly induced after influenza A virus infection in nasal epithelium. We also propose that type III IFNs are the primary IFNs to mediate an anti-viral defense in nasal epithelium and more sensitively reacted with ROS which were produced after respiratory virus infection. We estimate that ROS are necessary for the innate immune response and trigger the induction of IFN-related innate immune response to resist respiratory virus infection in human respiratory mucosa.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Arnoult D / 2009 / The role of mitochondria in cellular defense against microbial infection / Semin Immunol 21 (4) : 223 ~ 232
Edwards MR / 2013 / Impaired innate interferon induction in severe therapy resistant atopic asthmatic children / Mucosal Immunol 6 (4) : 797 ~ 806
Fialkow L / 2007 / Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function / Free Radic Biol Med 42 (2) : 153 ~ 164
Garcia-Sastre A / 2006 / Type 1 interferons and the virus-host relationship: a lesson in detente / Science 312 (5775) : 879 ~ 882
Haller O / 2006 / The interferon response circuit: induction and suppression by pathogenic viruses / Virology 344 (1) : 119 ~ 130
Edwards MR / 2013 / Impaired innate interferon induction in severe therapy resistant atopic asthmatic children / Mucosal Immunol 6 (4) : 797 ~ 806
Fialkow L / 2007 / Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function / Free Radic Biol Med 42 (2) : 153 ~ 164
Garcia-Sastre A / 2006 / Type 1 interferons and the virus-host relationship: a lesson in detente / Science 312 (5775) : 879 ~ 882
Haller O / 2006 / The interferon response circuit: induction and suppression by pathogenic viruses / Virology 344 (1) : 119 ~ 130
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