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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 317 - 322 (6page)
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초록· 키워드
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CCCTC-binding factor (CTCF), a zinc finger protein, is a transcription factor and regulator of chromatin structure. Forebrain excitatory neuron-specific CTCF deficiency contributes to inflammation via enhanced transcription of inflammation-related genes in the cortex and hippocampus. However, little is known about the long-term effect of CTCF deficiency on postnatal neurons, astrocytes, or microglia in the hippocampus of adult mice. To address this, we knocked out the Ctcf gene in forebrain glutamatergic neurons (Ctcf cKO) by crossing Ctcf-floxed mice with Camk2a-Cre mice and examined the hippocampi of 7.5-10-month-old male mice using immunofluorescence microscopy. We found obvious neuronal cell death and reactive gliosis in the hippocampal cornu ammonis (CA)1 in 7.5-10-month-old cKO mice. Prominent rod-shaped microglia that participate in immune surveillance were observed in the stratum pyramidale and radiatum layer, indicating a potential increase in inflammatory mediators released by hippocampal neurons. Although neuronal loss was not observed in CA3, and dentate gyrus (DG) CTCF depletion induced a significant increase in the number of microglia in the stratum oriens of CA3 and reactive microgliosis and astrogliosis in the molecular layer and hilus of the DG in 7.5-10-month-old cKO mice. These results suggest that long-term Ctcf deletion from forebrain excitatory neurons may contribute to reactive gliosis induced by neuronal damage and consequent neuronal loss in the hippocampal CA1, DG, and CA3 in sequence over 7 months of age.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ong CT / 2014 / CTCF : an architectural protein bridging genome topology and function / Nat Rev Genet 15:234~246
Moore JM / 2012 / Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos / PLoS One 7:e34915
Watson LA / 2014 / Dual effect of CTCF loss on neuroprogenitor differentiation and survival / J Neurosci 34:2860~2870
Gregor A / 2013 / De novo mutations in the genome organizer CTCF cause intellectual disability / Am J Hum Genet 93:124~131
Iossifov I / 2014 / The contribution of de novo coding mutations to autism spectrum disorder / Nature 515:216~221
Moore JM / 2012 / Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos / PLoS One 7:e34915
Watson LA / 2014 / Dual effect of CTCF loss on neuroprogenitor differentiation and survival / J Neurosci 34:2860~2870
Gregor A / 2013 / De novo mutations in the genome organizer CTCF cause intellectual disability / Am J Hum Genet 93:124~131
Iossifov I / 2014 / The contribution of de novo coding mutations to autism spectrum disorder / Nature 515:216~221
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