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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 5 (5page)
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CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and promoters. CTCF can also recruit other transcription factors while bound to chromatin domain boundaries. The three-dimensional organization of the eukaryotic genome dictates its function, and CTCF serves as one of the core architectural proteins that help establish this organization. The mapping of CTCF-binding sites in diverse species has revealed that the genome is covered with CTCF-binding sites. Here we briefly describe the diverse roles of CTCF that contribute to genome organization and gene expression.
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)]
Bell AC / 1999 / The protein CTCF is required for the enhancer blocking activity of vertebrate insulators / Cell 98 : 387 ~ 396
Chen H / 2012 / Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome / PLoS One 7 : e41374 ~
Chen X / 2008 / Integration of external signaling pathways with the core transcriptional network in embryonic stem cells / Cell 133 : 1106 ~ 1117
Chung JH / 1993 / A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila / Cell 74
Bell AC / 1999 / The protein CTCF is required for the enhancer blocking activity of vertebrate insulators / Cell 98 : 387 ~ 396
Chen H / 2012 / Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome / PLoS One 7 : e41374 ~
Chen X / 2008 / Integration of external signaling pathways with the core transcriptional network in embryonic stem cells / Cell 133 : 1106 ~ 1117
Chung JH / 1993 / A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila / Cell 74
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Birth of an ‘Asian cool’ reference genome: AK1
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