지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 445 - 453 (9page)
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초록· 키워드
오류제보하기
CTCF, Zinc-finger protein, has been identified as a multifunctional transcription factor that regulates gene expression through various mechanisms, including recruitment of other co-activators and binding to promoter regions of target genes.
Furthermore, it has been proposed to be an insulator protein that contributes to the establishment of functional threedimensional chromatin structures. It can disrupt transcription through blocking the connection between an enhancer and a promoter. Previous studies revealed that the onset of various diseases, including breast cancer, could be attributed to the aberrant expression of CTCF itself or one or more of its target genes. In this review, we will describe molecular dysfunction involving CTCF that induces tumorigenesis and summarize the functional roles of CTCF in breast cancer.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Aulmann S / 2003 / CTCF gene mutations in invasive ductal breast cancer / Breast Cancer Res Treat 80 : 347 ~ 352
Barutcu AR / 2016 / SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells / Genome Res 26 : 1188 ~ 1201
Bastaki F / 2017 / Identification of a novel CTCF mutation responsible for syndromic intellectual disability - a case report / BMC Med Genet 18 : 68 ~
Braikia FZ / 2017 / Inducible CTCF insulator delays the IgH 3' regulatory regionmediated activation of germline promoters and alters class switching / Proc Natl Acad Sci U S
Bruckheimer E / 1993 / Russell-Silver syndrome and Wilms tumor / J Pediatr 122 : 165 ~ 166
Barutcu AR / 2016 / SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells / Genome Res 26 : 1188 ~ 1201
Bastaki F / 2017 / Identification of a novel CTCF mutation responsible for syndromic intellectual disability - a case report / BMC Med Genet 18 : 68 ~
Braikia FZ / 2017 / Inducible CTCF insulator delays the IgH 3' regulatory regionmediated activation of germline promoters and alters class switching / Proc Natl Acad Sci U S
Bruckheimer E / 1993 / Russell-Silver syndrome and Wilms tumor / J Pediatr 122 : 165 ~ 166
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